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Ultraviolet（ UV）-and UV-related cytokine-mediated transcriptional mechanisms of type VII collagen gene（ COL7A1） expression in the skin, with special reference to photoaged skin and anti-aging
http://hdl.handle.net/10129/2230
http://hdl.handle.net/10129/223004b2595b-770a-4fbb-8d63-c27a15dd7d3b
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HirosakiMedJ_59_S154.pdf (712.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||
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| 公開日 | 2009-09-18 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Ultraviolet（ UV）-and UV-related cytokine-mediated transcriptional mechanisms of type VII collagen gene（ COL7A1） expression in the skin, with special reference to photoaged skin and anti-aging | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| キーワード | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | type VII collagen | |||||||||||||
| キーワード | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | COL7A1 | |||||||||||||
| キーワード | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | anchoring fibril | |||||||||||||
| キーワード | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | ultraviolet radiation | |||||||||||||
| キーワード | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | photo-aging | |||||||||||||
| キーワード | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | anti-aging | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | journal article | |||||||||||||
| 著者 |
Kon, Atsushi
× Kon, Atsushi
× Igarashi, Manami
× Yamaguchi, Masanori
× Kojima, Kaoru
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| 著者所属 | ||||||||||||||
| Department of Glycotechnology, Hirosaki University Graduate School of Medicine | ||||||||||||||
| 著者所属 | ||||||||||||||
| Department of Glycotechnology, Hirosaki University Graduate School of Medicine | ||||||||||||||
| 著者所属 | ||||||||||||||
| Department of Glycotechnology, Hirosaki University Graduate School of Medicine | ||||||||||||||
| 著者所属 | ||||||||||||||
| Department of Glycotechnology, Hirosaki University Graduate School of Medicine | ||||||||||||||
| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Chronic ultraviolet （UV） radiation results in photoaged skin characterized by deep wrinkle formation. Recent studies suggest that diminishment of anchoring fi brils（ AF）, stabilizing the association of the basement membrane to the underlying dermis, are involved in photoaged skin. Expression of COL7A1, encoding type VII collagen that is a major component of AF, is also decreased in photoaged skin. In this study, we have investigated COL7A1 transcription by UV and UV-related cytokines involved in photoaged skin. Nuclear run-on assay, luciferase assay and gel shift assay revealed that UV and UV-related cytokines（ TNF-α, IL-1β） tissue specifi cally downregulated COL7A1 transcription in epidermal keratinocytes, whereas COL7A1 transcription was upregulated by each modulator in dermal fi broblasts. The responsive element of each modulator was located between nucleotide -524 and -22 of COL7A1 promoter and AP-1 and NF-κB families band to this region. Taken together, these data strongly suggest that the downregulation of COL7A1 transcription in epidermal keratinocytes, main cells expressing COL7A1 in the skin, and subsequent diminishment of AF are involved in photoaged skin. We also have discussed relation between these results and pathophysiology of wrinkle formation, characteristic feature of photoaged skin. |
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| 引用 | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 内容記述 | 弘前医学. 59(Suppl.), 2007, p.S154-S161 | |||||||||||||
| 書誌情報 |
弘前医学 巻 59, 号 Supplement, p. S154-S161, 発行日 2007-11-29 |
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| ISSN | ||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||
| 収録物識別子 | 0439-1721 | |||||||||||||
| 書誌レコードID | ||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||
| 収録物識別子 | AN00211444 | |||||||||||||
| フォーマット | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 内容記述 | application/pdf | |||||||||||||
| 著者版フラグ | ||||||||||||||
| 出版タイプ | VoR | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||
| 日本十進分類法 | ||||||||||||||
| 主題Scheme | NDC | |||||||||||||
| 主題 | 491.4 | |||||||||||||
| NIIサブジェクト | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | 基礎医学 | |||||||||||||
| 出版者 | ||||||||||||||
| 出版者 | 弘前大学大学院医学研究科・弘前医学会 | |||||||||||||
| 資源タイプ | ||||||||||||||
| 値 | Article | |||||||||||||
