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New functions of classical hormone α-melanophore-stimulating hormone
http://hdl.handle.net/10129/2237
http://hdl.handle.net/10129/2237f82ce29c-779b-4078-a5bd-d28c98b2383a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HirosakiMedJ_59_S202.pdf (1.7 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-09-18 | |||||
| タイトル | ||||||
| タイトル | New functions of classical hormone α-melanophore-stimulating hormone | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | α-melanophore-stimulating hormone (α-MSH) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | low temperature | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Fos | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | hyperalgesia; interleukin-1β (IL-1β) | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Tonosaki, Yoshikazu
× Tonosaki, Yoshikazu× Sugiura, Yasuo× Roubos, Eric W. |
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| 著者所属 | ||||||
| 値 | Department of Anatomical Science, Hirosaki University Graduate School of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Functional Anatomy and Neuroscience, Nagoya University Graduate School of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Cellular Animal Physiology, Institute for Neuroscience, Radboud University | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | It is well-known that α-melanophore-stimulating hormone （α-MSH） release from the amphibian pars intermedia（ PI） depends on the light condition of the animal’s background. In the present study, we present two new functions of α-MSH in amphibians and mammals. In Xenopus laevis, we show that temperatures below 8 ℃ stimulate α-MSH secretion of the PI and skin darkening, with a maximum at 5 ℃, under regulation of the hypothalamus rule, independently from the illumination state of the background. The cold-induced α-MSH release of the PI was inhibited by neuropeptide-Y-producing suprachiasmatic-melanotrope-inhibiting neurons in the ventrolateral area of the suprachiasmatic nucleus but increasely in thyrotropin-releasing-hormene-containing neurons of the magnocellular nucleus. It is known that intracerebroventricular（ ICV） administration of a low dose of interleukin-1β（ IL-1β） induces hyperalgesia in rat and that this eff ect can be inhibited by α-MSH. To identify the part of the brain that is aff ected by hyperalgesiainducing IL-1β and the site of α-MSH concerned, we have examined Fos expression in the brain in response to ICV microinjection of α-MSH and/or IL-1β. Following injection of 10 pg IL-1β, hyperalgesia was induced and Fos became expressed in the paraventricular nucleus（ PVN） of the hypothalamus and in the arcuate nucleus（ ARC）, which contains α-MSH-producing neurons. ICV co-injection of IL-1β ・ with 30 ng α-MSH fully inhibited both hyperalgesia and Fos expression in the PVN and the ARC. We conclude that PVN neurons are activated by hyperalgesic IL-1β and propose that this eff ect is abolished by α-MSH released from the ARC but not from the pituitary gland. |
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| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 弘前医学. 59(Suppl.), 2007, p.S202-S209 | |||||
| 書誌情報 |
弘前医学 巻 59, 号 Supplement, p. S202-S209, 発行日 2007-11-29 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0439-1721 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00211444 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 491 | |||||
| NIIサブジェクト | ||||||
| 主題Scheme | Other | |||||
| 主題 | 基礎医学 | |||||
| 出版者 | ||||||
| 出版者 | 弘前大学大学院医学研究科・弘前医学会 | |||||
| 資源タイプ | ||||||
| 値 | Article | |||||
