| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2009-09-18 |
| タイトル |
|
|
タイトル |
Staphylococcal enterotoxin a modulates intracellular Ca^2+ signal pathway in human intestinal epithelial cells |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Hu, Dong-Liang
Suga, Yochiko
Omoe, Katsuhiko
Abe, Yoshinao
Shinagawa, Kunihiro
Wakui, Makoto
Nakane, Akio
|
| 著者所属 |
|
|
値 |
Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
値 |
Department of Physiology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
値 |
Department of Veterinary Microbiology, Faculty of Agriculture, Iwate University |
| 著者所属 |
|
|
値 |
Department of Radiology and Radiation Oncology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
値 |
Department of Veterinary Microbiology, Faculty of Agriculture, Iwate University |
| 著者所属 |
|
|
値 |
Department of Physiology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
値 |
Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
To clarify whether SEA can aff ect any changes of cellular signalling pathways in intestinal epithelial cells, weperformed experiments to see if SEA can modulate the intracellular signaling pathway in intestinal epithelial cells. Wedemonstrate here that SEA induces an increase in intracellular calcium（ ［Ca2+］i） in human intestinal epithelial cells andthe［ Ca2+］i is released from intracellular stores. SEA-induced increase of［ Ca2+］i was clearly inhibited by treatment witha nitric oxide synthase（ NOS） inhibitor, NG-monomethyl-L-arginine. Intestinal epithelial cells express endothelial NOS（eNOS） in resting cell condition, and express inducible NOS（ iNOS） after stimulating with tumor necrosis factor（ TNF）-α. TNF-α-pretreated cells showed a signifi cant increase in［ Ca2+］i that was also inhibited by the NOS inhibitor. Theseresults demonstrate that SEA induces an increase in intracellular Ca2+ concentration in human intestinal epithelial cells,and the expressions of both eNOS and iNOS could be responsible for the increase in intracellular Ca2+ concentration inthe cells induced by SEA. It is important to study the relationship of NOS expression, Ca2+ signal pathway and emesisfor understanding the mechanism of SEA-induced food poisoning. |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
弘前医学. 59(Suppl.), 2007, p.S219-S226 |
| 書誌情報 |
弘前医学
巻 59,
号 Supplement,
p. S219-S226,
発行日 2007-11-29
|
| ISSN |
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|
収録物識別子タイプ |
ISSN |
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収録物識別子 |
0439-1721 |
| 書誌レコードID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00211444 |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 日本十進分類法 |
|
|
主題Scheme |
NDC |
|
主題 |
491 |
| NIIサブジェクト |
|
|
主題Scheme |
Other |
|
主題 |
基礎医学 |
| 出版者 |
|
|
出版者 |
弘前大学大学院医学研究科・弘前医学会 |
| 資源タイプ |
|
|
値 |
Article |
HirosakiMedJ_59_S219.pdf (804.4 kB)
