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Mechanisms for brain sex diff erentiation
http://hdl.handle.net/10129/2243
http://hdl.handle.net/10129/224330ab2bbf-da1c-421b-92e0-5c2807fd01f0
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HirosakiMedJ_59_S253.pdf (2.0 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||
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| 公開日 | 2009-09-18 | |||||||
| タイトル | ||||||||
| タイトル | Mechanisms for brain sex diff erentiation | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| 著者 |
Sakuma, Yasuo
× Sakuma, Yasuo
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| 著者所属 | ||||||||
| 値 | Department of Physiology, Nippon Medical School | |||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Distinctive sex diff erences in reproductive behavior and physiology have been attributed not to diff erences in hormones gonad secretes in each sex but differences in particular brain structures. Interestingly enough, brain sex difference is determined mostly by gonadal hormones during ontogeny independent of genetic sex. In many laboratory mammals, brain sex can be manipulated at a particular stage of ontogeny called critical period for brain sex diff erentiation, by endocrine treatments. Thus, neonatal orchidectomy or administration of gonadal hormones to female pups reverses brain sex phenotype which culminates in sex-specifi c functions. The early, transient exposure to gonadal hormones or its absence leaves indelible marks on brain phenotype. This organizing action of gonadal hormones, combined with activational action of the hormones after puberty, accomplishes sex specific functions. Brain would undergo sex diff erentiation through neurogenesis, migration, or survival in addition to regulation of ion channels and other functional molecule. Two distinct structures, the sexually dimorphic nucleus of the preoptic area, which is larger in male rats than in males and the anteroventral periventricular nucleus, which furnish opposite characteristics, will provide good opportunity to understand the mechanism of brain sex diff erentiation. |
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| 引用 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | 弘前医学. 59(Suppl.), 2007, p.S253-S261 | |||||||
| 書誌情報 |
弘前医学 巻 59, 号 Supplement, p. S253-S261, 発行日 2007-11-29 |
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| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 0439-1721 | |||||||
| 書誌レコードID | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AN00211444 | |||||||
| フォーマット | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | application/pdf | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 日本十進分類法 | ||||||||
| 主題Scheme | NDC | |||||||
| 主題 | 491.3 | |||||||
| NIIサブジェクト | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | 基礎医学 | |||||||
| 出版者 | ||||||||
| 出版者 | 弘前大学大学院医学研究科・弘前医学会 | |||||||
| 資源タイプ | ||||||||
| 値 | Article | |||||||
