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Experimental Studies on Morphological Changes of the Epididymis and Testis in Neonatally Estrogenized Mice Revisited
http://hdl.handle.net/10129/1890
http://hdl.handle.net/10129/18900fe9bad5-9ab3-49a2-8999-c9dcfb5217bd
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HirosakiMedJ_59_S278.pdf (168.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2009-05-26 | |||||||||
| タイトル | ||||||||||
| タイトル | Experimental Studies on Morphological Changes of the Epididymis and Testis in Neonatally Estrogenized Mice Revisited | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | perinatal sex steroids | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | development of reproductive organs | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | epididymo-testicular inflammatory change | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | autoimmune disease | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | regulatory T lymphocyte | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| 著者 |
Kachi, Takashi
× Kachi, Takashi
× Kachi, Hitomi
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| 著者(ヨミ) | ||||||||||
| 識別子Scheme | WEKO | |||||||||
| 識別子 | 9620 | |||||||||
| 姓名 | カチ, タカシ | |||||||||
| 著者(ヨミ) | ||||||||||
| 識別子Scheme | WEKO | |||||||||
| 識別子 | 11941 | |||||||||
| 姓名 | カチ, ヒトミ | |||||||||
| 著者別名 | ||||||||||
| 識別子Scheme | WEKO | |||||||||
| 識別子 | 9624 | |||||||||
| 姓名 | 加地, 隆 | |||||||||
| 著者所属 | ||||||||||
| Department of Anatomical Science, Hirosaki University Graduate School of Medicine | ||||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Our primary concern in this review is to give possible explanations and pose new questions on the phenomena concerning effects of neonatal estrogen exposure on the development and functions of reproductive organs and immune mechanisms particularly in male animals, in the light of new findings and cencepts. At first, our own experimental results on the pathological changes in the epididymis and testis in neonatally estrogenized mice have been presented. The results of our first experiment showed that neonatal single injection of 10 flg of estradiol benzoate induced marked inflammatory changes in the epididymis and testis, in which the initial pathological change occurred concomitantly with the appearance of sperms in the epididymal duct. The second experiment showed that such epididymo-testicular changes did not occur when the testis was removed or neonatal estrogen was followed by testosterone. From these results, a possibility was suggested that a hormone-related autoimmune mechanism might participate in such changes. Relating to these, various reports concerning effects of neonatal estrogen treatment, either alone or with concommitent treatment with androgen. on the development and functions of reproductive organs and immune mechanisms in the adolescent or adult have been reviewed. In addition, advances in the related areas, such as estrogen-related mechanisms in the development and functions of reproductive organs and immune mechanisms including autoimmune disease mechanisms. gender differences and the role of CD25+ CD4+ T lymphocytes have also been reviewed briefly. |
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| 引用 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 弘前医学. 59(Suppl.), 2007, p.S278-287 | |||||||||
| 書誌情報 |
弘前医学 巻 59, 号 Suppl., p. S278-S287, 発行日 2007-11-29 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 0439-1721 | |||||||||
| 書誌レコードID | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AN00211444 | |||||||||
| フォーマット | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | application/pdf | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 日本十進分類法 | ||||||||||
| 主題Scheme | NDC | |||||||||
| 主題 | 491.1 | |||||||||
| NIIサブジェクト | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | 基礎医学 | |||||||||
| 出版者 | ||||||||||
| 出版者 | 弘前大学大学院医学研究科・弘前医学会 | |||||||||
| 資源タイプ | ||||||||||
| 値 | Article | |||||||||
