| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2010-08-02 |
| タイトル |
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|
タイトル |
＜Symposium I＞Prandial increases of leptin and orexin in the brain modulate spatial learning and memory |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Leptin |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Orexin |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
CaMK II phosphorylation |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Facilitation and impairment of learning and memory in rodents |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Oomura, Yutaka
Aou, Shuji
Fukunaga, Kouji
Moriguchi, Sigeki
Sasaki, Kazuo
|
| 著者所属 |
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Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University |
| 著者所属 |
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Department of Brain Science and Engineering, Graduate School of Life Science and Systems Engineering, Kitakyushu Institute of Technology |
| 著者所属 |
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Department of Pharmacology, Faculty of Pharmacy, Tohoku University |
| 著者所属 |
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Department of Pharmacology, Faculty of Pharmacy, Tohoku University |
| 著者所属 |
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Division of Bio-Information Engineering, Faculty of Engineering, University of |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
Leptin is well known to be involved in the inhibition of feeding, thermogenesis, reproduction and neuroendocrine functions through its actions on the rodent hypothalamic receptors. Leptin facilitated the presynaptic transmitter release and postsynaptic sensitivity to the transmitters in the hippocampal CA1 neurons. Thus longterm potentiation （LTP） and the phosphorylation of Ca2+/calmodulin protein kinase II （CaMK II） were facilitated in the CA1 neurons. Therefore behavioral performance related to spatial learning and memory was improved by leptin in vivo applications. Orexin-A produced by glucose-sensitive neurons in the lateral hypothalamic area （LHA）and released during food intake facilitates feeding. Orexin-A suppressed LTP and CaMK II phosphorylation without affecting the presynaptic transmitter release. Therefore behavioral performance on learning and memory was impaired. The present studies suggest that leptin and orexin signalings in the brain may have important implications for cognitive function. |
| 引用 |
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内容記述タイプ |
Other |
|
内容記述 |
弘前医学. 61(Suppl.), 2010, p.S1-S10 |
| 書誌情報 |
弘前医学
巻 61,
号 Supplement,
p. S1-S10,
発行日 2010-07-08
|
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0439-1721 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00211444 |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 日本十進分類法 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| NIIサブジェクト |
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|
主題Scheme |
Other |
|
主題 |
医学 |
| 出版者 |
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出版者 |
弘前大学大学院医学研究科・弘前医学会 |
| 資源タイプ |
|
|
値 |
Article |
HirosakiMedJ_61_S1.pdf (409.4 kB)
