| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2010-08-16 |
| タイトル |
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タイトル |
＜Symposium I＞Roles of DEC1 and DEC2 in the core loop of the circadian clock, and clock outputs to metabolism |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Kato, Yukio
Noshiro, Mitsuhide
Fujimoto, Katsumi
Kawamoto, Takeshi
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| 著者所属 |
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値 |
Department of Dental and Medical Biochemistry, Hiroshima University Graduate School of Biomedical |
| 著者所属 |
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|
値 |
Department of Dental and Medical Biochemistry, Hiroshima University Graduate School of Biomedical |
| 著者所属 |
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|
値 |
Department of Dental and Medical Biochemistry, Hiroshima University Graduate School of Biomedical |
| 著者所属 |
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値 |
Department of Dental and Medical Biochemistry, Hiroshima University Graduate School of Biomedical |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
We cloned Dec1 （Differentiated embryonic chondrocyte-1） and a similar gene, Dec2, in 1997 and 2000, respectively. DEC structure is similar to that of HES1 and HAIRY, and we observed circadian rhythms of Dec1 mRNA levels in chondrocytes in vitro and rat liver in vivo. We then attempted to fi nd out whether these genes are implicated in the circadian pacemaker: We found that a mutation of Clock abolishes or shifts circadian expression of Dec1 and/or Dec2 in most tissues, including the suprachiasmatic nucleus（ SCN）, and that DEC1 and DEC2 modulate their own circadian expression and that of some other clock genes by auto-regulatory and interlocked feedback mechanisms. Studies on defi ciencies of these genes indicate that Dec1 and Dec2 play roles in the phase shift and maintenance of accurate circadian rhythms and clock outputs to some physiological activities. We speculate that clock genes, including Dec, are involved in the pathology of various diseases and aging. |
| 引用 |
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内容記述タイプ |
Other |
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内容記述 |
弘前医学. 61(Suppl.), 2010, p.S34-S42 |
| 書誌情報 |
弘前医学
巻 61,
号 Supplement,
p. S34-S42,
発行日 2010-07-08
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0439-1721 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AN00211444 |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 日本十進分類法 |
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主題Scheme |
NDC |
|
主題 |
490 |
| NIIサブジェクト |
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主題Scheme |
Other |
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主題 |
医学 |
| 出版者 |
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出版者 |
弘前大学大学院医学研究科・弘前医学会 |
| 資源タイプ |
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値 |
Article |
HirosakiMedJ_61_S34.pdf (468.9 kB)
