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<Symposium III>Pathology of neuro-glial α-synucleinopathy (Lewy body disease and multiple system atrophy)
http://hdl.handle.net/10129/3673
http://hdl.handle.net/10129/3673d8a4171c-90a0-4b28-b095-05465273587d
名前 / ファイル | ライセンス | アクション |
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HirosakiMedJ_61_S80.pdf (343.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-08-16 | |||||
タイトル | ||||||
タイトル | <Symposium III>Pathology of neuro-glial α-synucleinopathy (Lewy body disease and multiple system atrophy) | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Parkinson’s disease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Lewy body | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | multiple system atrophy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | glial cytoplasmic inclusion | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | α-synuclein | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Wakabayashi, Koichi
× Wakabayashi, Koichi× Miki, Yasuo× Tanji, Kunikazu× Mori, Fumiaki |
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著者(ヨミ) | ||||||
姓名 | ワカバヤシ, コウイチ | |||||
著者(ヨミ) | ||||||
姓名 | ミキ, ヤスオ | |||||
著者(ヨミ) | ||||||
姓名 | タンジ, クニカズ | |||||
著者(ヨミ) | ||||||
姓名 | モリ, フミアキ | |||||
著者別名 | ||||||
姓名 | 若林, 孝一 | |||||
著者別名 | ||||||
姓名 | 三木, 康生 | |||||
著者別名 | ||||||
姓名 | 丹治, 邦和 | |||||
著者別名 | ||||||
姓名 | 森, 文秋 | |||||
著者所属 | ||||||
Department of Neuropathology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Neuropathology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Neuropathology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Neuropathology, Hirosaki University Graduate School of Medicine | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | α-Synucleinopathies comprise a group of neurodegenerative disorders that share α-synuclein (αS)accumulation in selected vulnerable neurons and glia, i.e. Parkinson’s disease (PD), dementia with Lewy bodies and multiple system atrophy( MSA). The histological hallmark of PD is neuronal αS aggregates called Lewy bodies( LBs). LB formation has been considered to be a marker for neuronal degeneration, because neuronal loss is found in the predilection sites for LBs. However, recent studies have suggested that oligomers and protofi brils of αS are cytotoxic, and that LBs may represent a cytoprotective mechanism in PD. The histological hallmark of MSA is αS aggregates in the oligodendrocytes referred to as glial cytoplasmic inclusions( GCIs). αS inclusions are also found in the neuronal somata, axons and nucleus. At present, two degenerative processes have been considered in this disease; one is due to the widespread occurrence of GCIs associated with oligodendroglia-myelin degeneration, and the other is due to the aggregation of αS in neurons in several brain regions. These two processes might synergistically cause neuronal depletion in MSA. | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 弘前医学. 61(Suppl.), 2010, p.S80-S88 | |||||
書誌情報 |
弘前医学 巻 61, 号 Supplement, p. S80-S88, 発行日 2010-07-08 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0439-1721 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00211444 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
日本十進分類法 | ||||||
主題Scheme | NDC | |||||
主題 | 490 | |||||
NIIサブジェクト | ||||||
主題Scheme | Other | |||||
主題 | 医学 | |||||
出版者 | ||||||
出版者 | 弘前大学大学院医学研究科・弘前医学会 | |||||
資源タイプ | ||||||
値 | Article |