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＜Poster＞Cellular and subcellular localizations of nonheme ferric and ferrous iron in the rat brain : a light and electron microscopic study by the perfusion-Perls and -Turnbull methods
http://hdl.handle.net/10129/3695
http://hdl.handle.net/10129/3695f41b1f23-65f9-4a1b-9982-0fdeaada8e5f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HirosakiMedJ_61_S245.pdf (278.1 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-08-19 | |||||
| タイトル | ||||||
| タイトル | ＜Poster＞Cellular and subcellular localizations of nonheme ferric and ferrous iron in the rat brain : a light and electron microscopic study by the perfusion-Perls and -Turnbull methods | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | nonheme iron | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | perfusion-Perls method | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | perfusion-Turnbull method | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Meguro, Reiko
× Meguro, Reiko× Asano, Yoshiya× Odagiri, Saori× Li, Chengtai× Shoumura, Kazuhiko× Ichinohe, Noritaka |
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| 著者(ヨミ) | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 12077 | |||||
| 姓名 | メグロ, レイコ | |||||
| 著者(ヨミ) | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 12078 | |||||
| 姓名 | アサノ, ヨシヤ | |||||
| 著者(ヨミ) | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 12076 | |||||
| 姓名 | オダギリ, サオリ | |||||
| 著者(ヨミ) | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 11213 | |||||
| 姓名 | ショウムラ, カズヒコ | |||||
| 著者(ヨミ) | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 12628 | |||||
| 姓名 | イチノヘ, ノリタカ | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 12082 | |||||
| 姓名 | 目黒, 玲子 | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 12083 | |||||
| 識別子Scheme | 研究者総覧 | |||||
| 識別子URI | http://hue2.jm.hirosaki-u.ac.jp/html/183_ja.html | |||||
| 識別子 | 183 | |||||
| 姓名 | 浅野, 義哉 | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 12081 | |||||
| 姓名 | 小田桐, 紗織 | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 11203 | |||||
| 姓名 | 正村, 和彦 | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 12633 | |||||
| 姓名 | 一戸, 紀孝 | |||||
| 著者所属 | ||||||
| 値 | Department of Neuroanatomy, Cell Biology and Histology, Hirosaki University Graduate School of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Neuroanatomy, Cell Biology and Histology, Hirosaki University Graduate School of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Neuroanatomy, Cell Biology and Histology, Hirosaki University Graduate School of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Neuroanatomy, Cell Biology and Histology, Hirosaki University Graduate School of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Neuroanatomy, Cell Biology and Histology, Hirosaki University Graduate School of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Neuroanatomy, Cell Biology and Histology, Hirosaki University Graduate School of Medicine | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Iron is essential for a variety of cellular functions. However iron, especially ferrous form, has the potential for catalyzing the Fenton reaction to generate highly cytotoxic hydroxyl radicals. Therefore the amount of iron in the brain is strictly controlled. In this study we focused on the cellular and subcellular localizations of nonheme ferric （Fe（III）） and ferrous （Fe（II）） iron in the adult female rat brain by light and electron microscopic histochemistry. Although Fe（II） deposition was much less dominant than Fe（III）, the brain contained iron in both forms. Among the cellular elements of the brain, oligodendrocytes were numerically most prominent and heavily iron-storing cells. Pericapillary astrocytes and sporadic microglial cells also showed dense iron accumulation. Large neurons involved in the motor system were relatively strongly iron-positive. Subcellularly, Fe（III） and Fe（II） were mainly localized in lysosomes, and occasionally in the cytosol and mitochondria. Fe（II）-specific deposit was shown on the luminal membrane of endothelium. With advancing age, both Fe（III） and Fe（II） became distributed more extensively, and accumulated more numerously into oligodendrocytes. | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 弘前医学. 61(Suppl.), 2010, p.S245-S251 | |||||
| 書誌情報 |
弘前医学 巻 61, 号 Supplement, p. S245-S251, 発行日 2010-07-08 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0439-1721 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00211444 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 490 | |||||
| NIIサブジェクト | ||||||
| 主題Scheme | Other | |||||
| 主題 | 医学 | |||||
| 出版者 | ||||||
| 出版者 | 弘前大学大学院医学研究科・弘前医学会 | |||||
| 資源タイプ | ||||||
| 値 | Article | |||||
