| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2015-05-25 |
| タイトル |
|
|
タイトル |
Tranilast Inhibits Proliferation of Pancreatic Stellate Cells and Activation of Pancreatic Fibrosis |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
alpha smooth muscle actin |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
platelet-derived growth factor |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
pancreatic stellate cells |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Transforming Growth Factor-β1 |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
tranilast |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Chikazawa, Shinji
Tando, Yusuke
Matsuhashi, Yuki
Yanagimachi, Miyuki
Nakamura, Teruo
Suda, Toshihiro
Daimon, Makoto
|
| 著者所属 |
|
|
値 |
Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
値 |
Department of Medical Life Science, Hirosaki University Graduate School of Health Science |
| 著者所属 |
|
|
値 |
Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
値 |
Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
値 |
Health Care Center Hirosaki Medical Association |
| 著者所属 |
|
|
値 |
Aomori Rosai Hospital |
| 著者所属 |
|
|
値 |
Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Chronic pancreatitis is histopathologically characterized by the progression of pancreatic fibrosis. Pancreatic stellate cells （PSCs） play a principal role in the development of pancreatic fibrosis. Tranilast suppresses collagen synthesis of fibroblasts derived from keloid hypertrophic scars and cell proliferation of fibroblasts. Hence, we hypothesize that tranilast suppresses fibrosis and is effective against pancreatic fibrosis. In this study, we examined the effect of tranilast on cell proliferation, activation, and collagen synthesis of cultured PSCs. Tranilast significantly inhibited the proliferation of PSCs when they were cultured with and without of platelet-derived growth factor （PDGF） and decreased the expression of alpha smooth muscle actin（ α-SMA） in cultures with Transforming Growth Factor-β1 （TGF-β1） and PDGF. Tranilast did not cause a significant dose-dependent reduction in the amount of collagen in the medium. Neither did it significantly affect the expression of Col-1 mRNA compared to the control. Our results suggest that tranilast inhibits the development of pancreatic fibrosis, making it a potential therapeutic agents for chronic pancreatitis. |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
弘前医学. 66, 2015, p.65-72 |
| 書誌情報 |
弘前医学
巻 66,
号 1,
p. 65-72,
発行日 2015-04-06
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0439-1721 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00211444 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 日本十進分類法 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| NIIサブジェクト |
|
|
主題Scheme |
Other |
|
主題 |
医学 |
| 出版者 |
|
|
出版者 |
弘前大学大学院医学研究科・弘前医学会 |
| 資源タイプ |
|
|
値 |
Article |
HirosakiMedJ_66(1)_65.pdf (1.1 MB)
