| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2016-03-31 |
| タイトル |
|
|
タイトル |
Beneficial Effect of 4-Methylumbelliferone Against Bile Duct Ligation-Induced Hepatic Fibrosis in Rats |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
liver fibrosis |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
hyaluronan |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
4-methylumbelliferone |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
alpha-smooth muscle actin |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
hepatic stellate cell |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Sawada, Naoya
Mikami, Kenichiro
Igarashi, Go
Endo, Tetsu
Sato, Ken
Kakizaki, Ikuko
Fukuda, Shinsaku
|
| 著者所属 |
|
|
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Department of Gastroenterology and Hematology, Hirosaki Graduate School of Medicine |
| 著者所属 |
|
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Department of Gastroenterology and Hematology, Hirosaki Graduate School of Medicine |
| 著者所属 |
|
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Department of Gastroenterology and Hematology, Hirosaki Graduate School of Medicine |
| 著者所属 |
|
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Department of Gastroenterology and Hematology, Hirosaki Graduate School of Medicine |
| 著者所属 |
|
|
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Department of Gastroenterology and Hematology, Hirosaki Graduate School of Medicine |
| 著者所属 |
|
|
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Department of Glycotechnology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
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Department of Gastroenterology and Hematology, Hirosaki Graduate School of Medicine |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background & Aims: Liver fibrosis progresses to cirrhosis as the consequence of chronic liver injury. 4-methylumbelliferone （4-MU）, a derivative of coumarin, has been used as an approved drug to treat biliary spasm. Recent publications have reported that 4-MU inhibits production of hyaluronan （HA）, which is a key component of extracellular matrix deposition in fibrotic and cirrhotic liver. We investigated the effect of 4-MU on fibrotic liver in rats.
Methods: Liver fibrosis was induced by bile duct ligation（ BDL）. Male Sprague-Dawley rats received a standard diet or the same diet containing 1% or 5% of 4-MU from 1 week before BDL. The rats were sacrificed at 3 weeks after BDL.
Results: Administration of 4-MU increased serum 4-MU concentration levels, thereby decreasing serum HA levels in a dose-dependent manner. 4-MU treatment suppressed liver fibrosis in interlobular and pericentral areas with reduced alpha-smooth muscle actin expression, which suggested hepatic stellate cell activation.
Conclusion: Treatment with 4-MU suppressed the experimental hepatic fibrosis accompanied by inhibition of HA production. Although further experimental studies are needed, 4-MU could protect against fibrogenesis and may be repurposed as a safe therapeutic application for hepatic fibrosis. |
| 引用 |
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内容記述タイプ |
Other |
|
内容記述 |
弘前医学. 66, 2016, p.143-151 |
| 書誌情報 |
弘前医学
巻 66,
号 2-4,
p. 143-151,
発行日 2016-03-25
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0439-1721 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00211444 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 日本十進分類法 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| NIIサブジェクト |
|
|
主題Scheme |
Other |
|
主題 |
医学 |
| 出版者 |
|
|
出版者 |
弘前大学大学院医学研究科・弘前医学会 |
| 資源タイプ |
|
|
値 |
Article |
HirosakiMedJ_66(2-4)_143.pdf (970.2 kB)
