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Association of Sex Steroid Hormones wth Neutrophil Function in the General Population
http://hdl.handle.net/10129/5917
http://hdl.handle.net/10129/5917833bb3b5-e350-46d2-ac8b-bf09e805e487
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HirosakiMedJ_67(1)_13.pdf (161.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-08-05 | |||||
| タイトル | ||||||
| タイトル | Association of Sex Steroid Hormones wth Neutrophil Function in the General Population | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | sex steroid hormones | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | neutrophil | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | reactive oxygen species | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | oxidative stress | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | general population | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Sato, Satoshi
× Sato, Satoshi× Komame, Hitomi× Akimoto, Naoki× Sawada, Kaori× Tanaka, Rina× Munakata, Osamu× Iizuka, Hiroshi× Shibata, Nobuyuki× Nakaji, Shigeyuki |
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| 著者所属 | ||||||
| 値 | Department of Social Medicine, Hirosaki University Graduate School of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Social Medicine, Hirosaki University Graduate School of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Social Medicine, Hirosaki University Graduate School of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Social Medicine, Hirosaki University Graduate School of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Social Medicine, Hirosaki University Graduate School of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Cancer Epidemiology and Community Health, Hirosaki University Graduate School of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Social Medicine, Hirosaki University Graduate School of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Social Medicine, Hirosaki University Graduate School of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Social Medicine, Hirosaki University Graduate School of Medicine | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | There are certain sex differences in the prevalence and severity of immunity-related diseases. Previous studies have shown the influence of sex steroid hormones, such as estrogen and testosterone, on the immune system. The aim of this study was to investigate the association of sex steroid hormones with neutrophil function among normal healthy subjects in the general population. Subjects included 540 residents（ 358 males and 182 females）, who participated in the Iwaki Health Promotion Project in 2014. We examined the association of estradiol and testosterone with neutrophil ROS production and phagocytic activity. As a result, estradiol and testosterone negatively correlated with basal ROS production in males and luteal phase females （>15th day of menstrual cycle）, although such trend was not observed in follicular phase females（ <14th day of menstrual cycle） and postmenopausal females. In contrast, the association of testosterone with stimulated ROS production and phagocytic activity was observed only in males. In conclusion, both estradiol and testosterone were found to have an influence on neutrophil function. Furthermore, the association of sex steroid hormones with neutrophil function was found to vary according to the phase of the menstrual cycle in addition to the sex difference. |
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| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 弘前医学. 67, 2016, p.13-27 | |||||
| 書誌情報 |
弘前医学 巻 67, 号 1, p. 13-27, 発行日 2016-07-29 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0439-1721 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00211444 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 490 | |||||
| NIIサブジェクト | ||||||
| 主題Scheme | Other | |||||
| 主題 | 医学 | |||||
| 出版者 | ||||||
| 出版者 | 弘前大学大学院医学研究科・弘前医学会 | |||||
| 資源タイプ | ||||||
| 値 | Article | |||||
