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  1. 30 医学部・医学研究科・保健学研究科
  2. 30b 弘前医学 = Hirosaki Medical Journal
  3. 67巻1号

Association of Sex Steroid Hormones wth Neutrophil Function in the General Population

http://hdl.handle.net/10129/5917
http://hdl.handle.net/10129/5917
833bb3b5-e350-46d2-ac8b-bf09e805e487
名前 / ファイル ライセンス アクション
HirosakiMedJ_67(1)_13.pdf HirosakiMedJ_67(1)_13.pdf (161.8 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2016-08-05
タイトル
タイトル Association of Sex Steroid Hormones wth Neutrophil Function in the General Population
言語
言語 eng
キーワード
主題Scheme Other
主題 sex steroid hormones
キーワード
主題Scheme Other
主題 neutrophil
キーワード
主題Scheme Other
主題 reactive oxygen species
キーワード
主題Scheme Other
主題 oxidative stress
キーワード
主題Scheme Other
主題 general population
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 Sato, Satoshi

× Sato, Satoshi

Sato, Satoshi

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Komame, Hitomi

× Komame, Hitomi

Komame, Hitomi

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Akimoto, Naoki

× Akimoto, Naoki

Akimoto, Naoki

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Sawada, Kaori

× Sawada, Kaori

Sawada, Kaori

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Tanaka, Rina

× Tanaka, Rina

Tanaka, Rina

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Munakata, Osamu

× Munakata, Osamu

Munakata, Osamu

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Iizuka, Hiroshi

× Iizuka, Hiroshi

Iizuka, Hiroshi

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Shibata, Nobuyuki

× Shibata, Nobuyuki

Shibata, Nobuyuki

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Nakaji, Shigeyuki

× Nakaji, Shigeyuki

Nakaji, Shigeyuki

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著者所属
値 Department of Social Medicine, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Social Medicine, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Social Medicine, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Social Medicine, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Social Medicine, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Cancer Epidemiology and Community Health, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Social Medicine, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Social Medicine, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Social Medicine, Hirosaki University Graduate School of Medicine
抄録
内容記述タイプ Abstract
内容記述 There are certain sex differences in the prevalence and severity of immunity-related diseases. Previous
studies have shown the influence of sex steroid hormones, such as estrogen and testosterone, on the immune system.
The aim of this study was to investigate the association of sex steroid hormones with neutrophil function among
normal healthy subjects in the general population. Subjects included 540 residents( 358 males and 182 females), who
participated in the Iwaki Health Promotion Project in 2014. We examined the association of estradiol and testosterone
with neutrophil ROS production and phagocytic activity. As a result, estradiol and testosterone negatively correlated
with basal ROS production in males and luteal phase females (>15th day of menstrual cycle), although such trend
was not observed in follicular phase females( <14th day of menstrual cycle) and postmenopausal females. In contrast,
the association of testosterone with stimulated ROS production and phagocytic activity was observed only in males.
In conclusion, both estradiol and testosterone were found to have an influence on neutrophil function. Furthermore,
the association of sex steroid hormones with neutrophil function was found to vary according to the phase of the menstrual cycle in addition to the sex difference.
引用
内容記述タイプ Other
内容記述 弘前医学. 67, 2016, p.13-27
書誌情報 弘前医学

巻 67, 号 1, p. 13-27, 発行日 2016-07-29
ISSN
収録物識別子タイプ ISSN
収録物識別子 0439-1721
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00211444
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
日本十進分類法
主題Scheme NDC
主題 490
NIIサブジェクト
主題Scheme Other
主題 医学
出版者
出版者 弘前大学大学院医学研究科・弘前医学会
資源タイプ
値 Article
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