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Interplay Between Autophagy and Pathogenic Bacteria : Toxins Secreted by Staphylococcus Aureus and Their Impact
http://hdl.handle.net/10129/6011
http://hdl.handle.net/10129/6011e51734af-3c49-452d-a979-195876efd9fd
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HirosakiMedJ_67(2-4)_115.pdf (870.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2017-03-09 | |||||||||
| タイトル | ||||||||||
| タイトル | Interplay Between Autophagy and Pathogenic Bacteria : Toxins Secreted by Staphylococcus Aureus and Their Impact | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Staphylococcus aureus | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | autophagy | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | intracellular pathogens | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | toxic shock syndrome toxin-1 | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | alpha-hemolysin | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| 著者 |
Asano, Krisana
× Asano, Krisana
× Nakane, Akio
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| 著者所属 | ||||||||||
| Department of Microbiology and Immunology, Hirosaki | ||||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Autophagy, a cellular homeostatic pathway, is emerged as an innate immune response against intracellular pathogens. It can directly eliminate invading bacteria by mediating their delivery to lysosomes. However, successful intracellular pathogens have developed mechanism（s） to escape or subvert autophagy for their intracellular niches. Studies on interplay between autophagy and intracellular pathogens are very important for understanding how infections occur. Particularly, Staphylococcus aureus is an important opportunistic pathogen that causes a wide range of infections. Classically, S. aureus is considered as an extracellular pathogen, but cumulative evidence indicates that this bacterium invades epithelial cells and replicates intracellularly which is relevant to intracellular persistence and chronic infections. A serious therapeutic problem of staphylococcal infections is caused by antibiotic resistant strains which have emerged increasingly in recent years. Thus, new insights in the strategy of S. aureus to interplay with autophagy is urgently required. This review highlights an impact of S. aureus toxins on autophagy. Alpha-hemolysin activates autophagy and prevents lysosome-autophagosome fusion, whereas toxic shock syndrome toxin-1 suppresses autophagosome formation. This opposite function indicates a complicated relationship between autophagy and intracellular adaptation of S. aureus. The possible effects of these toxins on S. aureus infections are also addressed in this review. |
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| 引用 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 弘前医学. 67, 2017, p.115-128 | |||||||||
| 書誌情報 |
弘前医学 巻 67, 号 2-4, p. 115-128, 発行日 2017-02-27 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 0439-1721 | |||||||||
| 書誌レコードID | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AN00211444 | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 日本十進分類法 | ||||||||||
| 主題Scheme | NDC | |||||||||
| 主題 | 490 | |||||||||
| NIIサブジェクト | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | 医学 | |||||||||
| 出版者 | ||||||||||
| 出版者 | 弘前大学大学院医学研究科・弘前医学会 | |||||||||
| 資源タイプ | ||||||||||
| 値 | Article | |||||||||
