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Suppression of the Rho/Rho-Kinase Pathway and Prevention of Cerebral Vasospasm by Combination Treatment with Statin and Fasudil After Subarachnoid Hemorrhage in Rabbit
http://hdl.handle.net/10129/5109
http://hdl.handle.net/10129/5109e62e76e2-d53d-4d84-9842-78585d280b4f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
内容要旨 (187.6 kB)
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本文 (1.7 MB)
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審査要旨 (94.3 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-12-20 | |||||
| タイトル | ||||||
| タイトル | Suppression of the Rho/Rho-Kinase Pathway and Prevention of Cerebral Vasospasm by Combination Treatment with Statin and Fasudil After Subarachnoid Hemorrhage in Rabbit | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cerebral vasospasm | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Pitavastatin | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Fasudil | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Rho/Rho-kinase pathway | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | eNOS | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 著者 |
Naraoka, Masato
× Naraoka, Masato× Munakata, Akira× Matsuda, Naoya× Shimamura, Norihito× Ohkuma, Hiroki |
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| 著者(ヨミ) | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 15650 | |||||
| 姓名 | ナラオカ, マサト | |||||
| 著者(ヨミ) | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 15651 | |||||
| 姓名 | ムナカタ, アキラ | |||||
| 著者(ヨミ) | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 14557 | |||||
| 姓名 | マツダ, ナオヤ | |||||
| 著者(ヨミ) | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 12508 | |||||
| 姓名 | シマムラ, ノリヒト | |||||
| 著者(ヨミ) | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 12509 | |||||
| 姓名 | オオクマ, ヒロキ | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 15655 | |||||
| 識別子Scheme | 研究者総覧 | |||||
| 識別子URI | http://hue2.jm.hirosaki-u.ac.jp/html/486_ja.html | |||||
| 識別子 | 486 | |||||
| 姓名 | 奈良岡, 征都 | |||||
| 著者所属 | ||||||
| 値 | Department of Neurosurgery, Hirosaki University School of Medicine, 5 Zaifu-cho, Hirosaki 036-8216, Japan | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The Rho/Rho-kinase pathway is considered important in the pathogenesis of sustained smooth muscle cell contraction during cerebral vasospasm after aneurysmal subarachnoid hemorrhage (SAH). The aims of this study were to investigate whether combination treatment, with pitavastatin as an inhibitor of RhoA and fasudil as an inhibitor of Rho-kinase, prevents the cerebral vasospasm. SAH was simulated using the double-hemorrhage rabbit model, and pitavastatin, or fasudil, or both (combination treatment) were administrated. The basilar artery (BA) cross-sectional area only in the combination treatment group was statistically larger than in the SAH group (p < 0.05). BA Rho-kinase, as measured by ELISA, was statistically reduced only in the combination treatment group compared with the SAH group (p < 0.05). In the other two treatment groups, pitavastatin or fasudil treatment group showed larger BA cross-sectional areas and lower value for BA Rho-kinase, but there were no statistically significant differences compared with the SAH group. The expression of endothelial nitric oxide synthase (eNOS), evaluated by immunohistochemistry in the pitavastatin group and the combination group, was higher than in the SAH group. Results indicate that combination treatment could extensively prevent cerebral vasospasm due to the synergic effect of combining pitavastatin and fasudil on the Rho/Rho-kinase pathway and on eNOS. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Open Access Article | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Translational Stroke Research, 4(3), 2013, p.368-374 | |||||
| 書誌情報 |
Translational Stroke Research 巻 4, 号 3, p. 368-374, 発行日 2013-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1868-4483 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA12507752 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s12975-012-0247-9 | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 494.62 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | ETD | |||||
| NIIサブジェクト | ||||||
| 主題Scheme | Other | |||||
| 主題 | 外科系臨床医学 | |||||
| 出版者 | ||||||
| 出版者 | Springer | |||||
| 資源タイプ | ||||||
| 値 | Thesis | |||||
| 学位名 | ||||||
| 学位名 | 博士（医学） | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 11101 | |||||
| 学位授与機関名 | 弘前大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2013-09-30 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲1807 | |||||
