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Hyperprolactinemia during antipsychotics treatment increases the level of coagulation markers
http://hdl.handle.net/10129/5668
http://hdl.handle.net/10129/5668478c5e86-6cdd-4ef8-9c64-2cbfd9a13054
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本文 (414.0 kB)
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審査要旨 (143.3 kB)
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内容要旨 (157.2 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2015-10-27 | |||||
| タイトル | ||||||
| タイトル | Hyperprolactinemia during antipsychotics treatment increases the level of coagulation markers | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | prolactin | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | antipsychotics | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | venous thromboembolism | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 著者 |
Ishioka, Masamichi
× Ishioka, Masamichi |
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| 著者(ヨミ) | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 16042 | |||||
| 姓名 | イシオカ, マサミチ | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 16043 | |||||
| 姓名 | 石岡, 雅道 | |||||
| 著者所属 | ||||||
| 値 | Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objective: The strong association between psychiatric patients who receive antipsychotics and the incidence of venous thromboembolism (VTE) is known. Although previous reports suggest that hyperprolactinemia often increases markers of activated coagulation, few studies have examined the direct relationship between the prolactin level elevated by antipsychotics and activated markers of activated coagulation. Method: The participants included 182 patients with schizophrenia (male =89, female =93) who received antipsychotic treatments for at least 3 months. Markers of VTE (D-dimer, fibrin/fibrinogen degradation products, and thrombin–antithrombin complex) and serum prolactin concentrations were measured. Results: Prolactin levels were significantly correlated with the logarithmic transformation of the D-dimer (r=0.320, P=0.002) and fibrin/fibrinogen degradation product levels (r=0.236, P=0.026) but not of the thrombin–antithrombin complex level (r=0.117, ns) among men. However, no correlations were found between the VTE markers and prolactin levels among women. These results were confirmed using multiple regression analyses that included demographic factors and antipsychotic dosages. Conclusion: The current study indicates that hyperprolactinemia is associated with an increase in markers of activated coagulation among men receiving antipsychotics. This finding clinically implies that monitoring and modulating prolactin levels among men are important to decrease the risk of VTE. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 掲載誌 Neuropsychiatric Disease and Treatment, 11, 2015, p.477-484 DOI http://dx.doi.org/10.2147/NDT.S75176 |
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| 書誌情報 |
Neuropsychiatric Disease and Treatment 巻 2015, 号 11, p. 477-484, 発行日 2015-09-30 |
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| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.2147/NDT.S75176 | |||||
| 著者版フラグ | ||||||
| 値 | ETD | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 491.5 | |||||
| その他のタイトル | ||||||
| その他のタイトル | 抗精神病薬投与中の高プロラクチン血症と凝固因子の関係 | |||||
| タイトル（ヨミ） | ||||||
| その他のタイトル | コウ セイシンビョウ ヤク トウヨ チュウ ノ コウ プロラクチン ケッショウ ト ギョウコ インシ ノ カンケイ | |||||
| NIIサブジェクト | ||||||
| 主題Scheme | Other | |||||
| 主題 | 基礎医学 | |||||
| 出版者 | ||||||
| 出版者 | Dove Press Ltd | |||||
| 資源タイプ | ||||||
| 値 | Thesis | |||||
| 学位名 | ||||||
| 学位名 | 博士（医学） | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 11101 | |||||
| 学位授与機関名 | 弘前大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2015-09-30 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲1907 | |||||
