| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2019-03-08 |
| タイトル |
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タイトル |
Preoperative chronic kidney disease predicts poor oncological outcomes after radical nephroureterectomy in patients with upper urinary tract urothelial carcinoma |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Kodama, Hirotake
Hatakeyama, Shingo
Fujita, Naoki
Iwamura, Hiromichi
Anan, Go
Fukushi, Ken
Narita, Takuma
Tanaka, Toshikazu
Kubota, Yuka
Horiguchi, Hirotaka
Momota, Masaki
Kido, Koichi
Matsumoto, Teppei
Soma, Osamu
Hamano, Itsuto
Yamamoto, Hayato
Tobisawa, Yuki
Yoneyama, Tohru
Yoneyama, Takahiro
Hashimoto, Yasuhiro
Koie, Takuya
Ito, Hiroyuki
Yoshikawa, Kazuaki
Sasaki, Atsushi
Kawaguchi, Toshiaki
Sato, Makoto
Ohyama, Chikara
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| 著者所属 |
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値 |
Hirosaki Univ, Dept Urol, Grad Sch Med |
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Hirosaki Univ, Dept Urol, Grad Sch Med |
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Hirosaki Univ, Dept Urol, Grad Sch Med |
| 著者所属 |
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値 |
Hirosaki Univ, Dept Urol, Grad Sch Med |
| 著者所属 |
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値 |
Hirosaki Univ, Dept Urol, Grad Sch Med |
| 著者所属 |
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値 |
Hirosaki Univ, Dept Urol, Grad Sch Med |
| 著者所属 |
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値 |
Hirosaki Univ, Dept Urol, Grad Sch Med |
| 著者所属 |
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Hirosaki Univ, Dept Urol, Grad Sch Med |
| 著者所属 |
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値 |
Hirosaki Univ, Dept Urol, Grad Sch Med |
| 著者所属 |
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Hirosaki Univ, Dept Urol, Grad Sch Med |
| 著者所属 |
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値 |
Hirosaki Univ, Dept Urol, Grad Sch Med |
| 著者所属 |
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Hirosaki Univ, Dept Urol, Grad Sch Med |
| 著者所属 |
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値 |
Hirosaki Univ, Dept Urol, Grad Sch Med |
| 著者所属 |
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Hirosaki Univ, Dept Urol, Grad Sch Med |
| 著者所属 |
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Hirosaki Univ, Dept Urol, Grad Sch Med |
| 著者所属 |
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値 |
Hirosaki Univ, Dept Urol, Grad Sch Med |
| 著者所属 |
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Hirosaki Univ, Dept Urol, Grad Sch Med |
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Hirosaki Univ, Dept Adv Transplant & Regenerat Med, Grad Sch Med |
| 著者所属 |
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値 |
Hirosaki Univ, Dept Urol, Grad Sch Med |
| 著者所属 |
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Hirosaki Univ, Dept Adv Transplant & Regenerat Med, Grad Sch Med |
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Hirosaki Univ, Dept Urol, Grad Sch Med |
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Aomori Rosai Hosp, Dept Urol |
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Mutsu Gen Hosp, Dept Urol |
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Tsugaru Gen Hosp, Dept Urol |
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Aomori Prefectural Cent Hosp, Dept Urol |
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Tohoku Med & Pharmaceut Univ, Dept Urol |
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Hirosaki Univ, Dept Urol, Grad Sch Med |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Objective: To evaluate the impact of preoperative chronic kidney disease (CKD) on oncological outcomes in patients with upper tract urothelial carcinoma who underwent radical nephroureterectomy.
Methods: A total of 426 patients who underwent radical nephroureterectomy at five medical centers between February 1995 and February 2017 were retrospectively examined. Oncological outcomes, including intravesical recurrence-free, visceral recurrence-free, cancer-specific, and overall survival rates (intravesical RFS, visceral RFS, CSS, and OS, respectively) stratified by preoperative CKD status (CKD vs. non-CKD) were investigated. Cox proportional hazards regression analysis was performed using inverse probability of treatment weighting (IPTW) to evaluate the impact of preoperative CKD on prognosis and a prognostic factor-based risk stratification nomogram was developed.
Results: Of the 426 patients, 250 (59%) were diagnosed with CKD before radical nephroureterectomy. Before the background adjustment, intravesical RFS, visceral RFS, CSS, and OS after radical nephroureterectomy were significantly shorter in the CKD group than in the non-CKD group. Background-adjusted IPTW analysis demonstrated that preoperative CKD was significantly associated with poor visceral RFS, CSS, and OS after radical nephroureterectomy. Intravesical RFS was not significantly associated with preoperative CKD. The nomogram for predicting 5-year visceral RFS and CSS probability demonstrated a significant correlation with actual visceral RFS and CSS (c-index = 0.85 and 0.83, respectively).
Conclusions: Upper tract urothelial carcinoma patients with preoperative CKD had a significantly lower survival probability than those without CKD. |
| 書誌情報 |
ONCOTARGET
巻 8,
号 47,
p. 83183-83194,
発行日 2017-10-10
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1949-2553 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.18632/oncotarget.20554 |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 資源タイプ |
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値 |
Article |
oncotarget-83183 (2.5 MB)
