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Retinoic Acid-Inducible Gene-i and CXCL10 are Involved in Biliary Atresia
http://hdl.handle.net/10129/00006586
http://hdl.handle.net/10129/0000658607c81385-6f8f-4cbb-918b-a3a53debf7ef
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HirosakiMedJ_69(1-4)_86.pdf (489.6 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-04-09 | |||||
| タイトル | ||||||
| タイトル | Retinoic Acid-Inducible Gene-i and CXCL10 are Involved in Biliary Atresia | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | biliary atresia | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | retinoic acid-inducible gene-I | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | CXCL10 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | HuCCT1 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | poly（I:C）. | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Kimura, Toshiro
× Kimura, Toshiro× Imaizumi, Tadaatsu× Yoshida, Tatsuya× Shimada, Taku× Hayakari, Ryo× Kawaguchi, Shogo× Yoshida, Hidemi× Kobayashi, Tamotsu× Hirabayashi, Takeshi× Mizukami, Hiroki× Kijima, Hiroshi× Hakamada, Kenichi |
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| 著者所属 | ||||||
| 値 | Department of Pediatric Surgery, Hirosaki University School of Medicine and Hospital | |||||
| 著者所属 | ||||||
| 値 | Department of Vascular Biology, Hirosaki University Graduate School of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Vascular Biology, Hirosaki University Graduate School of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Vascular Biology, Hirosaki University Graduate School of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Vascular Biology, Hirosaki University Graduate School of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Gastroenterology and Hematology,Hirosaki University Graduate School of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Vascular Biology, Hirosaki University Graduate School of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Pediatric Surgery, Hirosaki University School of Medicine and Hospital | |||||
| 著者所属 | ||||||
| 値 | Department of Pediatric Surgery, Hirosaki University School of Medicine and Hospital | |||||
| 著者所属 | ||||||
| 値 | Department of Pathology and Molecular Medicine,Hirosaki University Graduate School of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Pathology and Bioscience, Hirosaki University Graduate School of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Pediatric Surgery, Hirosaki University School of Medicine and Hospital | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: Retinoic acid-inducible gene-I （RIG-I） is a member of cytoplasmic viral sensors which plays an important role in inflammation of biliary epithelial cells（ BECs）. The aim of this study is to examine if RIG-I and C-X-C motif chemokine 10（ CXCL10） are involved in the etiology of human biliary atresia（ BA）. Methods: Immunohistochemical study was performed on surgically resected tissues obtained（ June 1994 to March 2016）from 30 infants with BA and non-inflamed hepatic tissues from 7 infants with hepatoblastoma. A semiquantitative scoring system was designed to evaluate the staining with an antibodies to the RIG-I and CXCL10. The expression of RIG-I and CXCL10 in HuCCT1 cholangiocarcinoma cell line were studied by western blotting, ELISA and RT-PCR analyses. Results: Intense immunoreactivity for RIG-I and CXCL10 was detected in BECs in tissues resected from BA patients.The expression of RIG-I and CXCL10 in the hilar tissue was significantly stronger than in the hepatic tissue.Transfection of HuCCT1 cells with poly（I:C）, a synthetic analog of viral dsRNA, induced the expression of RIG-I, and knockdown of RIG-I inhibited the induction of CXCL10 in HuCCT1 cells transfected with poly（I:C）. Conclusion: These results suggest that RIG-I-CXCL10 cascade may be involved in the etiology of human BA. |
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| 書誌情報 |
弘前医学 巻 69, 号 1-4, p. 86-94, 発行日 2019-03-15 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0439-1721 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00211444 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 490 | |||||
| 出版者 | ||||||
| 出版者 | 弘前大学大学院医学研究科・弘前医学会 | |||||
