| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2019-04-10 |
| タイトル |
|
|
タイトル |
Changes in Gut Microbiota Composition with Aging in Obese Adults |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
aging |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
general population |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
gut microbiota |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
lifestyle |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
obesity |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Tanaka, Rina
Matsuzaka, Masashi
Takahashi, Ippei
Sawada, Kaori
Nakaji, Shigeyuki
Sasaki, Yoshihiro
|
| 著者所属 |
|
|
値 |
Department of Medical Informatics, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
値 |
Department of Medical Informatics, Hirosaki University Hospital |
| 著者所属 |
|
|
値 |
Department of Faculty of Education, Hirosaki University |
| 著者所属 |
|
|
値 |
Department of Social Medicine, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
値 |
Department of Social Medicine, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
値 |
Department of Medical Informatics, Hirosaki University Graduate School of Medicine |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
It has been reported that an association between gut microbiota and obesity, and changes in the composition of gut microbiota have been reported with aging. The aim of this study is clarify the relationship between obesity and gut microbiota as a function of age. Furthermore, the impact of lifestyle factors（ alcoholic drink and smoking） on gut microbiota were discussed. Fecal samples from 1082 healthy Japanese adults aged 19–90 years who participated in the Iwaki Health Promotion Project in 2014 were analyzed by using 16S rDNA gene-targeted sequencing. The participants were stratified into six age groups: ≤39, 40–49, 50–59, 60–69, 70–79 and ≥80. The participants with a body mass index （BMI） of <25 kg/m2 were classified as non-obese, and those with a BMI of ≥25 kg/m2 were classified as obese. Changes in the composition of gut microbiota with age were different between the obese and non-obese groups.Bacterial diversity decreased with age at the phylum level, however, this diversity was not observed at the class level. The abundances of certain gut microbiota, such as Bacteroidetes and Firmicutes, were different between the obese and non-obese groups. There were no significant differences in alcoholic and smoking habits. Bacterial diversity was different with age between the obese and non-obese group. The composition of Bacteroidetes and Firmicutes changed with increasing age in the obese group. |
| 書誌情報 |
弘前医学
巻 69,
号 1-4,
p. 108-118,
発行日 2019-03-15
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0439-1721 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00211444 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 日本十進分類法 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 出版者 |
|
|
出版者 |
弘前大学大学院医学研究科・弘前医学会 |
HirosakiMedJ_69(1-4)_108.pdf (541.6 kB)
