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  1. 30 医学部・医学研究科・保健学研究科
  2. 30b 弘前医学 = Hirosaki Medical Journal
  3. 69巻1-4号

Changes in Gut Microbiota Composition with Aging in Obese Adults

http://hdl.handle.net/10129/00006588
http://hdl.handle.net/10129/00006588
5e6c73c8-beeb-4551-8533-5866c222030d
名前 / ファイル ライセンス アクション
HirosakiMedJ_69(1-4)_108.pdf HirosakiMedJ_69(1-4)_108.pdf (541.6 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2019-04-10
タイトル
タイトル Changes in Gut Microbiota Composition with Aging in Obese Adults
言語
言語 eng
キーワード
主題Scheme Other
主題 aging
キーワード
主題Scheme Other
主題 general population
キーワード
主題Scheme Other
主題 gut microbiota
キーワード
主題Scheme Other
主題 lifestyle
キーワード
主題Scheme Other
主題 obesity
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 Tanaka, Rina

× Tanaka, Rina

Tanaka, Rina

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Matsuzaka, Masashi

× Matsuzaka, Masashi

Matsuzaka, Masashi

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Takahashi, Ippei

× Takahashi, Ippei

Takahashi, Ippei

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Sawada, Kaori

× Sawada, Kaori

Sawada, Kaori

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Nakaji, Shigeyuki

× Nakaji, Shigeyuki

Nakaji, Shigeyuki

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Sasaki, Yoshihiro

× Sasaki, Yoshihiro

Sasaki, Yoshihiro

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著者所属
値 Department of Medical Informatics, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Medical Informatics, Hirosaki University Hospital
著者所属
値 Department of Faculty of Education, Hirosaki University
著者所属
値 Department of Social Medicine, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Social Medicine, Hirosaki University Graduate School of Medicine
著者所属
値 Department of Medical Informatics, Hirosaki University Graduate School of Medicine
抄録
内容記述タイプ Abstract
内容記述 It has been reported that an association between gut microbiota and obesity, and changes in the composition of gut microbiota have been reported with aging. The aim of this study is clarify the relationship between obesity and gut microbiota as a function of age. Furthermore, the impact of lifestyle factors( alcoholic drink and smoking) on gut microbiota were discussed. Fecal samples from 1082 healthy Japanese adults aged 19–90 years who participated in the Iwaki Health Promotion Project in 2014 were analyzed by using 16S rDNA gene-targeted sequencing. The participants were stratified into six age groups: ≤39, 40–49, 50–59, 60–69, 70–79 and ≥80. The participants with a body mass index (BMI) of <25 kg/m2 were classified as non-obese, and those with a BMI of ≥25 kg/m2 were classified as obese. Changes in the composition of gut microbiota with age were different between the obese and non-obese groups.Bacterial diversity decreased with age at the phylum level, however, this diversity was not observed at the class level. The abundances of certain gut microbiota, such as Bacteroidetes and Firmicutes, were different between the obese and non-obese groups. There were no significant differences in alcoholic and smoking habits. Bacterial diversity was different with age between the obese and non-obese group. The composition of Bacteroidetes and Firmicutes changed with increasing age in the obese group.
書誌情報 弘前医学

巻 69, 号 1-4, p. 108-118, 発行日 2019-03-15
ISSN
収録物識別子タイプ ISSN
収録物識別子 0439-1721
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00211444
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
日本十進分類法
主題Scheme NDC
主題 490
出版者
出版者 弘前大学大学院医学研究科・弘前医学会
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