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  1. 30 医学部・医学研究科・保健学研究科
  2. 30b 弘前医学 = Hirosaki Medical Journal
  3. 70巻1号

Remarkable effects of salvage chemotherapy with cetuximab and paclitaxel after cancer immunotherapy in two cases of recurrent/metastatic head and neck cancer

http://hdl.handle.net/10129/00006853
http://hdl.handle.net/10129/00006853
0078aca6-aa7c-495c-b22e-d648d2df107a
名前 / ファイル ライセンス アクション
HirosakiMedJ_70(1)_72.pdf HirosakiMedJ_70(1)_72 (483.8 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2019-11-22
タイトル
タイトル Remarkable effects of salvage chemotherapy with cetuximab and paclitaxel after cancer immunotherapy in two cases of recurrent/metastatic head and neck cancer
言語
言語 eng
キーワード
主題Scheme Other
主題 Cancer immunotherapy
キーワード
主題Scheme Other
主題 Chemotherapy
キーワード
主題Scheme Other
主題 Anti-PD-1 antibody
キーワード
主題Scheme Other
主題 Head and neck cancer
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 Kudo, Naomi

× Kudo, Naomi

Kudo, Naomi

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Abe, Takahisa

× Abe, Takahisa

Abe, Takahisa

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Midorikawa, Shin

× Midorikawa, Shin

Midorikawa, Shin

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Matsubara, Atsushi

× Matsubara, Atsushi

Matsubara, Atsushi

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著者所属
値 Department of Otorhinolaryngology, Hirosaki University Graduate School of Medicine
抄録
内容記述タイプ Abstract
内容記述 In recent years, anti-programmed cell death 1( PD-1) antibody has been approved for recurrent/metastatic head and neck cancer and was reported by the phase 3 study ChackMate 141 to improve the overall survival rate of patients with recurrent/metastatic head and neck squamous cell carcinoma. With the increasing number of cases treated with anti-PD-1 antibody, the synergic interaction between cancer immunotherapy and chemotherapy has been gathering attention. Some reported that administration of chemotherapy after immunotherapy was remarkably effective for progressive non-small cell lung cancer. We examined two notable cases of recurrent/metastatic head and neck cancer in which the subsequent administration of chemotherapy after immunotherapy was markedly effective. The two cases included maxillary sinus cancer and laryngeal cancer that were treated with radiotherapy and chemotherapy as first-line treatment. Both cases developed recurrent/metastatic lesion that were treated with anti-PD-1 antibody. However, the lesions increased in size after immunotherapy. Therefore, subsequent chemotherapy with cetuximab and paclitaxel was considered and showed marked reduction of size of the recurrent/metastatic lesions. The two cases suggested that administration of salvage chemotherapy after immunotherapy is promising for recurrent/ metastatic head and neck cancer.
書誌情報 弘前医学

巻 70, 号 1, p. 72-76, 発行日 2019-11-01
ISSN
収録物識別子タイプ ISSN
収録物識別子 0439-1721
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00211444
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
出版者
出版者 弘前大学大学院医学研究科・弘前医学会
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