| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2020-03-06 |
| タイトル |
|
|
タイトル |
Mutational analysis of β-arrestin in Japanese patients with coronary spastic angina |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Coronary spastic angina |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Prinzmetal variant angina |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
β-arrestin |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Mutational analysis |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Direct sequencing |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Kudo, Natsumi
Hanada, Kenji
Kawamura, Yosuke
Nakata, Masamichi
Nozaka, Masashi
Kitayama, Kazutaka
Miura, Naotake
Tanaka, Makoto
Osanai, Tomohiro
Tomita, Hirofumi
|
| 著者所属 |
|
|
値 |
Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
値 |
Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
値 |
Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
値 |
Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
値 |
Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
値 |
Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
値 |
Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
値 |
Department of Stroke and Cerebrovascular Medicine, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
値 |
Department of Health Promotion, Hirosaki University Graduate School of Health Sciences |
| 著者所属 |
|
|
値 |
Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Coronary spastic angina （CSA） has become increasingly important for clinical practice. β-arrestin regulates a large network of cellular responses including inflammation and muscle contraction. However, little is known about its role in the pathogenesis of CSA. In this study, we performed mutational analysis of β-arrestin1 and β-arrestin2 genes in CSA patients. The study population included 20 CSA patients and 5 control subjects. Mutational analyses of the coding egions of β-arrestins were performed by direct sequencing. In β-arrestin1, single base heterozygous substitution at nucleotide position 176 in exon 5 was detected in 2 of 20 CSA patients, whereas no substitution was detected in control subjects. We subsequently performed an association study involving 50 CSA patients and 50 control subjects. No ifference was found in the incidence of the mutation between the two groups （p=0.44）. In β-arrestin2, single base substitution at nucleotide position 61 in exon 11 was detected. This substitution was homozygous in 13 and heterozygous in 7 of 20 CSA patients, whereas all homozygous in 5 control subjects. These substitutions were well-annotated SNPs rs877711 and rs1045280, respectively） and did not cause amino acid replacement. No significant substitution of the oding regions of β-arrestins was detected in Japanese CSA patients. |
| 書誌情報 |
弘前医学
巻 70,
号 2-4,
p. 148-155,
発行日 2020-03-02
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0439-1721 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00211444 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 出版者 |
|
|
出版者 |
弘前大学大学院医学研究科 |
Hirosaki Med J 70-2-4_148 (939.6 kB)
