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Ketamine pharmacokinetics in recipients and donors of ABO blood type-compatible and -incompatible living kidney transplantation
http://hdl.handle.net/10129/00006965
http://hdl.handle.net/10129/00006965d9763b1c-5956-45e7-a2be-a2a26569e03c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Hirosaki Med J 70-2-4_156 (776.0 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||
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| 公開日 | 2020-03-06 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Ketamine pharmacokinetics in recipients and donors of ABO blood type-compatible and -incompatible living kidney transplantation | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Ketamine | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Living kidney transplantation | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | ABO blood type-compatible and -incompatible kidney transplantation | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Pharmacokinetics | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Graft function | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| 著者 |
Matsumoto, Anna
× Matsumoto, Anna
× Kushikata, Tetsuya
× Hirota, Kazuyoshi
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| 著者所属 | ||||||||||||
| 値 | Department of Anesthesiology, Hirosaki University Hospital | |||||||||||
| 著者所属 | ||||||||||||
| 値 | Department of Anesthesiology, Hirosaki University Graduate School of Medicine | |||||||||||
| 著者所属 | ||||||||||||
| 値 | Department of Anesthesiology, Hirosaki University Graduate School of Medicine | |||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | In kidney transplantation, stable hemodynamics is essential to preserve graft function. We used ketamine as an anesthetic because of its sympathomimetic properties. On the other hand, ketamine has several adverse effects, such as prolonged emergence from anesthesia or psychological reactions. Altered ketamine pharmacokinetics was previously reported in rabbits with renal nsufficiency, but no study has examined human living kidney transplantation, which has the potential to cause renal nsufficiency in the donor and recipient. Therefore, we evaluated ketamine pharmacokinetics in the donor and recipient of living kidney transplantation in various situation including ABO blood type-compatible and -incompatible transplantation. Materials and Methods: We examined the ketamine pharmacokinetics in donors （n=8）, and ABO blood type -compatible （n=8） and -incompatible （n=8） recipients of living kidney transplantation. We also measured the estimated glomerular filtration ratio（ eGFR）, blood urea nitrogen（ BUN）, and serum creatinine in these patients. Results: The time course of changes in the ketamine level after stopping ketamine administration did not differ between the donors and recipients. We also found that the eGFR in recipients gradually improved 48 h after the kidney transplantation. No patient developed ketamine-related adverse effects or allograft rejection. Conclusion: We conclude that ketamine can be safely applied as an adjuvant with intravenous anesthesia during ABO blood type-compatible and -incompatible living kidney transplantation. |
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| 書誌情報 |
弘前医学 巻 70, 号 2-4, p. 156-162, 発行日 2020-03-02 |
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| ISSN | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 0439-1721 | |||||||||||
| 書誌レコードID | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AN00211444 | |||||||||||
| 著者版フラグ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | 弘前大学大学院医学研究科 | |||||||||||
