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Relationship between red blood cell aging and intracellular chemokine storage
http://hdl.handle.net/10129/00007247
http://hdl.handle.net/10129/000072470d32a049-a1b7-40ac-bca0-8d0394498d26
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Hirosaki Med J 71-2-4_113 (236.6 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-03-11 | |||||
| タイトル | ||||||
| タイトル | Relationship between red blood cell aging and intracellular chemokine storage | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | RBC | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | DARC | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | chemokine | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | HbA1c | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | accumulation | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Ogasawara, shu
× Ogasawara, shu× Saito, Norihiro× Minakawa, Satoko× Akasaka, Tomomi× Kayaba, Hiroyuki |
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| 著者所属 | ||||||
| 値 | Clinical Laboratory, Hirosaki University Hospital Department of Clinical Laboratory Medicine, Hirosaki University Graduate School of Medicine | |||||
| 著者所属 | ||||||
| 値 | Clinical Laboratory, Hirosaki University Hospital Department of Clinical Laboratory Medicine, Hirosaki University Graduate School of Medicine | |||||
| 著者所属 | ||||||
| 値 | Clinical Laboratory, Hirosaki University Hospital | |||||
| 著者所属 | ||||||
| 値 | Clinical Laboratory, Hirosaki University Hospital | |||||
| 著者所属 | ||||||
| 値 | Clinical Laboratory, Hirosaki University Hospital Department of Clinical Laboratory Medicine, Hirosaki University Graduate School of Medicine | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: The Duffy antigen receptor for chemokines （DARC） is expressed on RBCs and is a non-signalingreceptor for multiple chemokines. In the previous study, we had shown that DARC-affinity chemokines are stored inthe RBCs. However, the fate of intracellularly stored chemokines has yet to be investigated. This study investigatedwhether RBCs retain the ability to accumulate these chemokines as they age. Methods: Peripheral blood from five healthy volunteers were collected, and then transferred to hematocrit capillarytubes. After centrifugation, the RBC layer was divided to compare the top, upper, middle and bottom fractions.HbA1c, eotaxin-1 and RANTES were measured in each fraction. Results: HbA1c increased significantly from the top fraction to the bottom fraction. Eotaxin-1 decreased significantlyfrom the top fraction to the bottom fraction. RANTES exhibited a similar decrease, although no significant differenceswere observed. Eotaxin-1 showed a negative correlation（ r = -0.51, p = 0.03） with HbA1c. Although not statisticallysignificant, RANTES showed a decreasing tendency （r = -0.40, p = 0.08） with the increase of HbA1c levels. Theseresults indicate that RANTES and eotaxin-1 decrease rather than increase with RBC aging. Conclusion: Eotaxin-1 and RANTES stored in RBCs tended to decrease as RBCs age. |
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| 書誌情報 |
弘前医学 巻 71, 号 2-4, p. 113-119, 発行日 2021-03-05 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0439-1721 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00211444 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | 弘前大学大学院医学研究科 | |||||
| 資源タイプ | ||||||
| 値 | Article | |||||
