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Changes in the Initial Distribution Volume of Glucose in Endotoxin-induced Septic Pig Models
http://hdl.handle.net/10129/00007771
http://hdl.handle.net/10129/000077712f9a2ad3-7989-4a3f-a0d7-6d67628c91f8
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Hirosaki Med J 72-1-4_6.pdf (327.6 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2022-04-22 | |||||
| タイトル | ||||||
| タイトル | Changes in the Initial Distribution Volume of Glucose in Endotoxin-induced Septic Pig Models | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Initial distribution volume of glucose | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cardiac preload | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | fluid volume monitoring | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Suganuma, Takuya
× Suganuma, Takuya× Hashiba, Eiji× Akaishi, Masahiro× Saito, Junichi× Hirota, Kazuyoshi |
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| 著者所属 | ||||||
| 値 | Department of Anesthesiology, Hirosaki university Graduate School of Medicine | |||||
| 著者所属 | ||||||
| 値 | Division of Intensive Care, Hirosaki University Hospital, Hirosaki | |||||
| 著者所属 | ||||||
| 値 | Department of Anesthesiology, Hirosaki university Graduate School of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Anesthesiology, Hirosaki university Graduate School of Medicine | |||||
| 著者所属 | ||||||
| 値 | Department of Anesthesiology, Hirosaki university Graduate School of Medicine | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Initial distribution volume of glucose （IDVG） has been demonstrated to reflect central extracellular fluid （ECF）volume and can be used as an indicator of cardiac preload. However, it is unknown whether IDVG reflects the cardiacpreload in septic patients. This study aimed to investigate the changes in IDVG in endotoxin（ ET）-induced septic pigmodels. METHODS: We anesthetized 13pigs and sepsis was induced with intravenous ET. Five pigs were used to investigatechanges in IDVG, 3pigs were used as controls and 5pigs underwent fluid resuscitation with Ringer’s lactate solutionsafter ET. IDVG was measured with 2g glucose and calculated with one compartment model. IDVG, CO, intrathoracicblood volume （ITBV）, and other parameters were measured after ET. The statistical analysis was performed withRM-ANOVA, followed by Dunnett’s test or the Newman-Keuls test. P<0.05 was considered significant. RESULTS: CO and systolic BP significantly decreased and lactate levels significantly increased 4h after ET. IDVGand ITBV significantly decreased but central venous pressure did not change 4h after ET. IDVG and CO weresignificantly increased with volume loading, but the effects disappeared after 1h. CONCLUSIONS: IDVG reflected the changes in the central ECF volumes and can be an indicator of cardiac preload in septic states. |
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| 書誌情報 |
弘前医学 巻 72, 号 1-4, p. 6-14, 発行日 2022-03-10 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0439-1721 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00211444 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | 弘前大学大学院医学研究科 | |||||
| 資源タイプ | ||||||
| 値 | Article | |||||
