Department of Pharmacology, Hirosaki University, Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, 036-8562, Japan
Department of Pharmacology, Graduate School of Medicine, University of Miyazaki 5200 Kihara Kiyotake Miyazaki, 889-1692, Japan
Department of Anesthesiology, Hirosaki University, Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, 036-8562, Japan
Department of Anesthesiology, Hirosaki University, Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, 036-8562, Japan
Department of Cellphysiology, Akita University School of Medicine, Akita, 010-8543, Japan
Department of Internal Medicine Division of Cardiovascular and Respiratory Medicine, Akita University School of Medicine, Akita, 010-8543, Japan
Department of Anesthesiology, Hirosaki University, Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, 036-8562, Japan
Department of Cellphysiology, Akita University School of Medicine, Akita, 010-8543, Japan
抄録
Aims: The purpose of the current study was to evaluate the significance of the endothelin system in catecholamine release and synthesis in the adrenal gland.
Main Methods: Primary cultures of isolated bovine adrenal medullary cells were prepared. Gene expression, intracellular calcium changes, epinephrine release, and other factors were investigated.
Key findings: Expression of endothelin receptors in the rat adrenal gland was confirmed. Intravenous infusion of endothelin-1 (1.0 nmol) increased blood pressure (systolic and diastolic). Endothelin-1 stimulated intracellular calcium changes, resulting in increased nuclear factor of T cell (NFAT) activity and epinephrine release from cultured adrenal medullary cells. Furthermore, endothelin-1 increased catecholamine synthesis and caused hypertrophic changes in the cell size.
Significance: Our findings indicate involvement of the endothelin system in the sympathetic regulation of the adrenal
medulla.
運用指針・許諾書
Involvement of Endothelin-1 in Adrenal Catecholamine Regulation
HirosakiMedJ_65(2-4)_218.pdf
(1.76MB)
