| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2014-11-14 |
| タイトル |
|
|
タイトル |
Involvement of Endothelin-1 in Adrenal Catecholamine Regulation |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
adrenal gland |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
calcium |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
catecholamine |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
blood pressure |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
endothelin |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Murakami, Manabu
Nemoto, Takayuki
Niwa, Hidetoshi
Kushikata, Tetsuya
Ono, Kyoichi
Watanabe, Hiroyuki
Hirota, Kazuyoshi
Ohba, Takayoshi
|
| 著者所属 |
|
|
値 |
Department of Pharmacology, Hirosaki University, Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, 036-8562, Japan |
| 著者所属 |
|
|
値 |
Department of Pharmacology, Graduate School of Medicine, University of Miyazaki 5200 Kihara Kiyotake Miyazaki, 889-1692, Japan |
| 著者所属 |
|
|
値 |
Department of Anesthesiology, Hirosaki University, Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, 036-8562, Japan |
| 著者所属 |
|
|
値 |
Department of Anesthesiology, Hirosaki University, Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, 036-8562, Japan |
| 著者所属 |
|
|
値 |
Department of Cellphysiology, Akita University School of Medicine, Akita, 010-8543, Japan |
| 著者所属 |
|
|
値 |
Department of Internal Medicine Division of Cardiovascular and Respiratory Medicine, Akita University School of Medicine, Akita, 010-8543, Japan |
| 著者所属 |
|
|
値 |
Department of Anesthesiology, Hirosaki University, Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, 036-8562, Japan |
| 著者所属 |
|
|
値 |
Department of Cellphysiology, Akita University School of Medicine, Akita, 010-8543, Japan |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Aims: The purpose of the current study was to evaluate the significance of the endothelin system in catecholamine release and synthesis in the adrenal gland.
Main Methods: Primary cultures of isolated bovine adrenal medullary cells were prepared. Gene expression, intracellular calcium changes, epinephrine release, and other factors were investigated.
Key findings: Expression of endothelin receptors in the rat adrenal gland was confirmed. Intravenous infusion of endothelin-1 (1.0 nmol) increased blood pressure (systolic and diastolic). Endothelin-1 stimulated intracellular calcium changes, resulting in increased nuclear factor of T cell (NFAT) activity and epinephrine release from cultured adrenal medullary cells. Furthermore, endothelin-1 increased catecholamine synthesis and caused hypertrophic changes in the cell size.
Significance: Our findings indicate involvement of the endothelin system in the sympathetic regulation of the adrenal
medulla. |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
弘前医学. 65(2-4), 2014, p.218-226 |
| 書誌情報 |
弘前医学
巻 65,
号 2-4,
p. 218-226,
発行日 2014-09-30
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0439-1721 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00211444 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 日本十進分類法 |
|
|
主題Scheme |
NDC |
|
主題 |
499 |
| NIIサブジェクト |
|
|
主題Scheme |
Other |
|
主題 |
薬学 |
| 出版者 |
|
|
出版者 |
弘前大学大学院医学研究科・弘前医学会 |
| 資源タイプ |
|
|
値 |
Article |
HirosakiMedJ_65(2-4)_218.pdf (1.8 MB)
