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Involvement of Endothelin-1 in Adrenal Catecholamine Regulation
http://hdl.handle.net/10129/5430
http://hdl.handle.net/10129/543057dfc307-9641-4c8a-9634-aab01607d83a
名前 / ファイル | ライセンス | アクション |
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HirosakiMedJ_65(2-4)_218.pdf (1.8 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-11-14 | |||||
タイトル | ||||||
タイトル | Involvement of Endothelin-1 in Adrenal Catecholamine Regulation | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | adrenal gland | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | calcium | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | catecholamine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | blood pressure | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | endothelin | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Murakami, Manabu
× Murakami, Manabu× Nemoto, Takayuki× Niwa, Hidetoshi× Kushikata, Tetsuya× Ono, Kyoichi× Watanabe, Hiroyuki× Hirota, Kazuyoshi× Ohba, Takayoshi |
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著者所属 | ||||||
Department of Pharmacology, Hirosaki University, Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, 036-8562, Japan | ||||||
著者所属 | ||||||
Department of Pharmacology, Graduate School of Medicine, University of Miyazaki 5200 Kihara Kiyotake Miyazaki, 889-1692, Japan | ||||||
著者所属 | ||||||
Department of Anesthesiology, Hirosaki University, Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, 036-8562, Japan | ||||||
著者所属 | ||||||
Department of Anesthesiology, Hirosaki University, Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, 036-8562, Japan | ||||||
著者所属 | ||||||
Department of Cellphysiology, Akita University School of Medicine, Akita, 010-8543, Japan | ||||||
著者所属 | ||||||
Department of Internal Medicine Division of Cardiovascular and Respiratory Medicine, Akita University School of Medicine, Akita, 010-8543, Japan | ||||||
著者所属 | ||||||
Department of Anesthesiology, Hirosaki University, Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, 036-8562, Japan | ||||||
著者所属 | ||||||
Department of Cellphysiology, Akita University School of Medicine, Akita, 010-8543, Japan | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Aims: The purpose of the current study was to evaluate the significance of the endothelin system in catecholamine release and synthesis in the adrenal gland. Main Methods: Primary cultures of isolated bovine adrenal medullary cells were prepared. Gene expression, intracellular calcium changes, epinephrine release, and other factors were investigated. Key findings: Expression of endothelin receptors in the rat adrenal gland was confirmed. Intravenous infusion of endothelin-1 (1.0 nmol) increased blood pressure (systolic and diastolic). Endothelin-1 stimulated intracellular calcium changes, resulting in increased nuclear factor of T cell (NFAT) activity and epinephrine release from cultured adrenal medullary cells. Furthermore, endothelin-1 increased catecholamine synthesis and caused hypertrophic changes in the cell size. Significance: Our findings indicate involvement of the endothelin system in the sympathetic regulation of the adrenal medulla. |
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引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 弘前医学. 65(2-4), 2014, p.218-226 | |||||
書誌情報 |
弘前医学 巻 65, 号 2-4, p. 218-226, 発行日 2014-09-30 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0439-1721 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00211444 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
日本十進分類法 | ||||||
主題Scheme | NDC | |||||
主題 | 499 | |||||
NIIサブジェクト | ||||||
主題Scheme | Other | |||||
主題 | 薬学 | |||||
出版者 | ||||||
出版者 | 弘前大学大学院医学研究科・弘前医学会 | |||||
資源タイプ | ||||||
値 | Article |