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Newly identifi ed message for rescue and repair from necrotic cell: Biology and clinical relevance of“endokine, HMGB1”
http://hdl.handle.net/10129/2210
http://hdl.handle.net/10129/2210dd814588-6493-401e-af2c-75973b9f04af
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HirosakiMedJ_59_S1.pdf (1.0 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||
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| 公開日 | 2009-09-18 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Newly identifi ed message for rescue and repair from necrotic cell: Biology and clinical relevance of“endokine, HMGB1” | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | sepsis | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | disseminated intravascular coagulation(DIC) | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | thrombomodulin | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | alarmin | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | highmobility group box 1 (HMGB1) | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| 著者 |
Maruyama, Ikuro
× Maruyama, Ikuro
× Ito, Takashi
× Hashiguchi, Teruto
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| 著者所属 | ||||||||||||
| Department of Laboratory and Vascular Medicine,Kagoshima University Graduate School of Medical and Dental Sciences | ||||||||||||
| 著者所属 | ||||||||||||
| Department of Laboratory and Vascular Medicine,Kagoshima University Graduate School of Medical and Dental Sciences | ||||||||||||
| 著者所属 | ||||||||||||
| Department of Laboratory and Vascular Medicine,Kagoshima University Graduate School of Medical and Dental Sciences | ||||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Responses to stimuli in cellar level are diverse and such hierarchical as secretion of stored factors, synthesis of lipid mediators and protein synthesis through genomic transcription. However, how can the cells respond in the case of necrosis? Recently a characteristic intranuclear protein, high-mobility group box 1 protein （HMGB1） is released from necrotic cells. The protein is an abundant nuclear protein with a dual function both inside and outside the cells. In physiological state, HMGB1 is present in the nucleus, and binds to DNA, playing a variety of crucial functions, including transcription and keeping the characteristic DNA architecture. However, the protein is released to extracellular space from most of necrotic cells, activated macrophages and dendritic cells. Out of the cells, HMGB1 acts as a signal of tissue damage and can promote infl ammation, immune responses, and results tissue regeneration. During sepsis and/or disseminated intravascular coagulation （DIC）, however, massive accumulation of HMGB1 in the systemic circulation will cause multiple organ failure （MOF） and subsequent lethal outcome. Thus HMGB1 in the systemic circulation has been considered as a lethal mediator of sepsis, and a promising therapeutic target for sepsis. Recently we identified that thrombomodulin （TM）, a natural anticoagulant glycoprotein expressed on the surface of endothelial cells, plays an important role in sequestering HMGB1. TM may prevent HMGB1 from reaching remote organs, thereby restricting the spectrum of HMGB1 action in the site of injury. Here we review recent progress made in defining the physiological and pathological roles of HMGB1 and therapeutic strategies aimed at blocking circulatory HMGB1. |
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| 引用 | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | 弘前医学. 59(Suppl.), 2007, p.S1-S11 | |||||||||||
| 書誌情報 |
弘前医学 巻 59, 号 Supplement, p. S1-S11, 発行日 2007-11-29 |
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| ISSN | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 0439-1721 | |||||||||||
| 書誌レコードID | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AN00211444 | |||||||||||
| フォーマット | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | application/pdf | |||||||||||
| 著者版フラグ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| 日本十進分類法 | ||||||||||||
| 主題Scheme | NDC | |||||||||||
| 主題 | 491 | |||||||||||
| NIIサブジェクト | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | 基礎医学 | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | 弘前大学大学院医学研究科・弘前医学会 | |||||||||||
| 資源タイプ | ||||||||||||
| 値 | Article | |||||||||||
