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New approaches for prevention and treatment of infl uenza virus infection by an enhancement of mucosal immunization and suppression of protease expression
http://hdl.handle.net/10129/2212
http://hdl.handle.net/10129/2212986b2922-81c5-4c18-b587-3be4b401151a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HirosakiMedJ_59_S19.pdf (2.7 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||
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| 公開日 | 2009-09-18 | |||||||||||||||||||
| タイトル | ||||||||||||||||||||
| タイトル | New approaches for prevention and treatment of infl uenza virus infection by an enhancement of mucosal immunization and suppression of protease expression | |||||||||||||||||||
| 言語 | ||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | influenza virus | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | mucosal immunization | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | pulmonary surfactant | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | ectopic trypsin | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | influenzaassociated encephalopathy | |||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||
| 著者 |
Kido, Hiroshi
× Kido, Hiroshi
× Mizuno, Dai
× Le, Quang Trong
× Chida, Junji
× Yamada, Hiroshi
× Okumura, Yuushi
× Yano, Mihiro
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| 著者所属 | ||||||||||||||||||||
| 値 | Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima | |||||||||||||||||||
| 著者所属 | ||||||||||||||||||||
| 値 | Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima | |||||||||||||||||||
| 著者所属 | ||||||||||||||||||||
| 値 | Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima | |||||||||||||||||||
| 著者所属 | ||||||||||||||||||||
| 値 | Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima | |||||||||||||||||||
| 著者所属 | ||||||||||||||||||||
| 値 | Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima | |||||||||||||||||||
| 著者所属 | ||||||||||||||||||||
| 値 | Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima | |||||||||||||||||||
| 著者所属 | ||||||||||||||||||||
| 値 | Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima | |||||||||||||||||||
| 抄録 | ||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||
| 内容記述 | Human infl uenza virus causes an annual epidemic infection. After infl uenza virus infection in the airway, infection sometimes spreads with severe neurologic complication and multiple organ failure, resulting in high mortality. In the process of viral spread from the lungs to other organs, signifi cant up-regulated trpsin was observed in various organs. Up-regulated trypsin eff ectively converted precursor of the viral envelope hemagglutinin（ HA） into HA1 and HA2 subunits. The proteolytic activation of HA is a prerequisite for virus multiplication. Administration of the inhibitors of trypsin as new approaches for the treatment of infl uenza virus infection eff ectively suppressed viral multiplication. Almost vaccines for infl uenza virus infection are administered i.m. or s.c., which induce IgG-mediated protection in the systemic immune compartment, but this immunization off ers insuffi cient protection on the mucosal surface at the initial site of viral multiplication. To improve protective mucosal immunity, intranasal vaccination has been studied. The powerful mucosal adjuvants reported are toxin based, such as cholera toxin and Escherichia coli heat-labile toxin, but these enterotoxins cause severe side eff ects. We recently found natural mucosal adjuvant, pulmonary surfactant, in the lungs. Intranasal administration of infl uenza vaccine combined with Surfacten, a modifi ed pulmonary surfactant free of antigenic c-type lectins, induced high protective mucosal immunity in the airway and systemic immune responses in the blood, the effi cacy of both protective immunities by Surfacten being equivalent to those by cholera toxin. In this symposium, we reported the eff ects of Surfacten on mucosal and systemic immunities. |
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| 引用 | ||||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||||
| 内容記述 | 弘前医学. 59(Suppl.), 2007, p.S19-S25 | |||||||||||||||||||
| 書誌情報 |
弘前医学 巻 59, 号 Supplement, p. S19-S25, 発行日 2007-11-29 |
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| ISSN | ||||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||||
| 収録物識別子 | 0439-1721 | |||||||||||||||||||
| 書誌レコードID | ||||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||||
| 収録物識別子 | AN00211444 | |||||||||||||||||||
| フォーマット | ||||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||||
| 内容記述 | application/pdf | |||||||||||||||||||
| 著者版フラグ | ||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||
| 日本十進分類法 | ||||||||||||||||||||
| 主題Scheme | NDC | |||||||||||||||||||
| 主題 | 493.8 | |||||||||||||||||||
| NIIサブジェクト | ||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | 内科系臨床医学 | |||||||||||||||||||
| 出版者 | ||||||||||||||||||||
| 出版者 | 弘前大学大学院医学研究科・弘前医学会 | |||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||
| 値 | Article | |||||||||||||||||||
