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IL-15-dependent cross-talk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation
http://hdl.handle.net/10129/2214
http://hdl.handle.net/10129/2214dae4aaf2-1048-4a7a-91cf-28caccc68565
名前 / ファイル | ライセンス | アクション |
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HirosakiMedJ_59_S35.pdf (1.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-09-18 | |||||
タイトル | ||||||
タイトル | IL-15-dependent cross-talk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | innate immunity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IL-12 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | TLR9 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Listeria monocytogenes | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ohteki, Toshiaki
× Ohteki, Toshiaki× Kuwajima, Seiichi |
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著者所属 | ||||||
Department of Immunology, Akita University, Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Immunology, Akita University, Graduate School of Medicine | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Unmethylated CpG oligodeoxynucleotides (CpG) prevalent in bacteria and DNA viruses bind Toll-like receptor( TLR) 9 and directly stimulate DCs, thereby activating the innate and adaptive immune responses. CpG is potentially a powerful reagent for protective immunity against infection by a wide variety of pathogens, for cancer and allergy therapies, and for the development of prophylactic and therapeutic vaccines. Here we investigated the role of interleukin (IL)-15 in the activation of CpG-induced immune responses. We show that upon CpG-priming, both wild-type( WT) and NK cell-depleted WT mice produce interleukin( IL)-12 p70 and become resistant to a lethal dose of Listeria monocytogenes( LM), whereas IL-15-/- mice impair IL-12 p70 production and succumb to the infection. Notably, CpG-stimulated conventional dendritic cells (cDCs) are the major producer of both IL-15 and IL-12 p70, but cDCs do not produce IL-12 in the absence of plasmacytoid DCs( pDCs) in vivo. Importantly, cDC-derived IL-15 induces CD40 expression on cDCs, which interacts with CD40 ligand on pDCs, leading to CD40 cross-linking and IL-12 production. Collectively, these fi ndings show that IL-15-dependent cross-talk between cDCs and pDCs is essential for CpG-induced immune activation( recently published in Nat Immunol 2006;7:740-6) |
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引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 弘前医学. 59(Suppl.), 2007, p.S35-S42 | |||||
書誌情報 |
弘前医学 巻 59, 号 Supplement, p. S35-S42, 発行日 2007-11-29 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0439-1721 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00211444 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
日本十進分類法 | ||||||
主題Scheme | NDC | |||||
主題 | 491.8 | |||||
NIIサブジェクト | ||||||
主題Scheme | Other | |||||
主題 | 基礎医学 | |||||
出版者 | ||||||
出版者 | 弘前大学大学院医学研究科・弘前医学会 | |||||
資源タイプ | ||||||
値 | Article |