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IL-15-dependent cross-talk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation
http://hdl.handle.net/10129/2214
http://hdl.handle.net/10129/2214dae4aaf2-1048-4a7a-91cf-28caccc68565
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HirosakiMedJ_59_S35.pdf (1.1 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2009-09-18 | |||||||||
| タイトル | ||||||||||
| タイトル | IL-15-dependent cross-talk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | innate immunity | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | IL-12 | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | TLR9 | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Listeria monocytogenes | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| 著者 |
Ohteki, Toshiaki
× Ohteki, Toshiaki
× Kuwajima, Seiichi
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| 著者所属 | ||||||||||
| 値 | Department of Immunology, Akita University, Graduate School of Medicine | |||||||||
| 著者所属 | ||||||||||
| 値 | Department of Immunology, Akita University, Graduate School of Medicine | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Unmethylated CpG oligodeoxynucleotides （CpG） prevalent in bacteria and DNA viruses bind Toll-like receptor（ TLR） 9 and directly stimulate DCs, thereby activating the innate and adaptive immune responses. CpG is potentially a powerful reagent for protective immunity against infection by a wide variety of pathogens, for cancer and allergy therapies, and for the development of prophylactic and therapeutic vaccines. Here we investigated the role of interleukin （IL）-15 in the activation of CpG-induced immune responses. We show that upon CpG-priming, both wild-type（ WT） and NK cell-depleted WT mice produce interleukin（ IL）-12 p70 and become resistant to a lethal dose of Listeria monocytogenes（ LM）, whereas IL-15-/- mice impair IL-12 p70 production and succumb to the infection. Notably, CpG-stimulated conventional dendritic cells （cDCs） are the major producer of both IL-15 and IL-12 p70, but cDCs do not produce IL-12 in the absence of plasmacytoid DCs（ pDCs） in vivo. Importantly, cDC-derived IL-15 induces CD40 expression on cDCs, which interacts with CD40 ligand on pDCs, leading to CD40 cross-linking and IL-12 production. Collectively, these fi ndings show that IL-15-dependent cross-talk between cDCs and pDCs is essential for CpG-induced immune activation（ recently published in Nat Immunol 2006;7:740-6） |
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| 引用 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 弘前医学. 59(Suppl.), 2007, p.S35-S42 | |||||||||
| 書誌情報 |
弘前医学 巻 59, 号 Supplement, p. S35-S42, 発行日 2007-11-29 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 0439-1721 | |||||||||
| 書誌レコードID | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AN00211444 | |||||||||
| フォーマット | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | application/pdf | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 日本十進分類法 | ||||||||||
| 主題Scheme | NDC | |||||||||
| 主題 | 491.8 | |||||||||
| NIIサブジェクト | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | 基礎医学 | |||||||||
| 出版者 | ||||||||||
| 出版者 | 弘前大学大学院医学研究科・弘前医学会 | |||||||||
| 資源タイプ | ||||||||||
| 値 | Article | |||||||||
