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Estrogen receptors in diseases of the immune system
http://hdl.handle.net/10129/2220
http://hdl.handle.net/10129/22205ebb6d98-96c6-4783-917b-e5528590dbc2
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HirosakiMedJ_59_S77.pdf (96.6 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2009-09-18 | |||||||||
| タイトル | ||||||||||
| タイトル | Estrogen receptors in diseases of the immune system | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| 著者 |
Warner, Margaret
× Warner, Margaret
× Gustafsson, Jan-Åke
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| 著者所属 | ||||||||||
| Department of Biosciences and Nutrition, Novum, Karolinska University Hospital, Huddinge, Karolinska Institutet | ||||||||||
| 著者所属 | ||||||||||
| Department of Biosciences and Nutrition, Novum, Karolinska University Hospital, Huddinge, Karolinska Institutet | ||||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Estrogen has distinct functions in the immune system where it acts via ERα and HERβ respectively. Surprisingly, the defects in the immune system which develop in the absence of either ERα or ERβ are quite distinct from what develops in the absence of estrogen. We have found by studying mice in which either or both estrogen receptors have been inactivated that the two estrogen receptors play distinct roles in the immune system. Loss of ERβ leads to chronic myeloid leukemia and loss of ERα leads to autoimmune disease. In mice which cannot synthesize estrogen there is also autoimmune disease resembling Sjögren’s Syndrome. We plan to study these mice further with the aim of fi nding the exact sites of action of the two receptors in the immune system and by using specifi c ligands for ERα. or ERβ to examine how specifi c parts of the immune system can be modifi ed. These studies should lead to improved treatment of patients with diseases of the immune system. |
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| 引用 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 弘前医学. 59(Suppl.), 2007, p.S77-S81 | |||||||||
| 書誌情報 |
弘前医学 巻 59, 号 Supplement, p. S77-S81, 発行日 2007-11-29 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 0439-1721 | |||||||||
| 書誌レコードID | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AN00211444 | |||||||||
| フォーマット | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | application/pdf | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 日本十進分類法 | ||||||||||
| 主題Scheme | NDC | |||||||||
| 主題 | 491.8 | |||||||||
| NIIサブジェクト | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | 基礎医学 | |||||||||
| 出版者 | ||||||||||
| 出版者 | 弘前大学大学院医学研究科・弘前医学会 | |||||||||
| 資源タイプ | ||||||||||
| 値 | Article | |||||||||
