| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2009-09-18 |
| タイトル |
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|
タイトル |
V1a vasopressin receptor gene single nucleotide polymorphism and essential hypertension, type 2 diabetes mellitus and platelet aggregation |
| 言語 |
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言語 |
eng |
| キーワード |
|
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主題Scheme |
Other |
|
主題 |
vasopressin V1a receptor |
| キーワード |
|
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主題Scheme |
Other |
|
主題 |
SNPs |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
essential hypertension |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
type 2 diabetes mellitus |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
platelets aggregation heterogeneity |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Hasan, Kazi N.
Shoji, Masaru
Sugimoto, Kazuhiro
Tsutaya, Shoji
Matsuda, Eriko
Kudo, Ryoko
Saito, Junko
Nakaji, Shigeyuki
Suda, Toshihiro
Yasujima, Minoru
|
| 著者所属 |
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|
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Department of Laboratory Medicine, Hirosaki University Graduate School of Medicine |
| 著者所属 |
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|
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Department of Laboratory Medicine, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
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Department of Clinical Laboratory, Hirosaki University Hospital |
| 著者所属 |
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Department of Clinical Laboratory, Hirosaki University Hospital |
| 著者所属 |
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Department of Clinical Laboratory, Hirosaki University Hospital |
| 著者所属 |
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Department of Clinical Laboratory, Hirosaki University Hospital |
| 著者所属 |
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Department of Clinical Laboratory, Hirosaki University Hospital |
| 著者所属 |
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Department of Social Medicine, Hirosaki University Graduate School of Medicine |
| 著者所属 |
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Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine |
| 著者所属 |
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Department of Laboratory Medicine, Hirosaki University Graduate School of Medicine |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
Candidate gene SNP study is a promising genetic approaches to complex common disorders. Argininevasopressin （AVP）, a peptide hormone released from the posterior pituitary, has been suggested to play importantroles in the regulation of blood pressure, glycogenolysis and platelet aggregation through G protein coupled V1areceptor （V1aR）. Thus, polymorphisms in the V1aR gene have been prospective as possible genetic markers foressential hypertension, type 2 diabetes mellitus and divergent platelet aggregation response to AVP. We identifi ed 4novel single nucleotide polymorphisms（ SNPs） in the promoter region of the V1aR gene and named according to theupstream locations such as, -6951G/A, -4112A/T, -3860T/C, and -242C/T. We investigated the association of 4 SNPs ofthe V1aR gene in 365 hypertensive and 255 healthy subjects, 186 T2DM patients and 188 non-diabetic control subjects（CS）, and 33 young healthy volunteers living in the Aomori prefecture. Signifi cant association was identifi ed betweenSNP at -6951 and hypertension in nonobese individuals, at -6951 and type 2 diabetes mellitus. Positive association wasalso identifi ed between nonobese hypertension and haplotype H3. Signifi cant association was demonstrated betweenSNP at -6951 and glycemic status in young healthy subjects. However, there was no signifi cant association in the AVPinducedplatelet aggregation with V1aR gene variants. The study suggests V1aR gene variants as increased riskfor hypertension in nonobese and type 2 diabetes mellitus in the Aomori population; however, might not be useful asgenetic markers for platelet aggregation heterogeneity. |
| 引用 |
|
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内容記述タイプ |
Other |
|
内容記述 |
弘前医学. 59(Suppl.), 2007, p.S119-S127 |
| 書誌情報 |
弘前医学
巻 59,
号 Supplement,
p. S119-S127,
発行日 2007-11-29
|
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0439-1721 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00211444 |
| フォーマット |
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内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 日本十進分類法 |
|
|
主題Scheme |
NDC |
|
主題 |
491 |
| NIIサブジェクト |
|
|
主題Scheme |
Other |
|
主題 |
基礎医学 |
| 出版者 |
|
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出版者 |
弘前大学大学院医学研究科・弘前医学会 |
| 資源タイプ |
|
|
値 |
Article |
HirosakiMedJ_59_S119.pdf (239.9 kB)
