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Continuous venovenous hemofi ltration improves endotoxin induced lung injury in pigs : Evaluation with ultrasonography
http://hdl.handle.net/10129/2226
http://hdl.handle.net/10129/222602e1700d-742b-487e-9f5f-77bbf627372d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HirosakiMedJ_59_S128.pdf (907.0 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2009-09-18 | |||||
| タイトル | ||||||
| タイトル | Continuous venovenous hemofi ltration improves endotoxin induced lung injury in pigs : Evaluation with ultrasonography | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Tsubo, Toshihito
× Tsubo, Toshihito× Fujita, Ayaka× Hashiba, Eiji× Ishihara, Hironori× Hirota, Kazuyoshi |
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| 著者所属 | ||||||
| 値 | Intensive Care Unit and Department of Anesthesiology, University of Hirosaki, Graduate School of Medicine | |||||
| 著者所属 | ||||||
| 値 | Intensive Care Unit and Department of Anesthesiology, University of Hirosaki, Graduate School of Medicine | |||||
| 著者所属 | ||||||
| 値 | Intensive Care Unit and Department of Anesthesiology, University of Hirosaki, Graduate School of Medicine | |||||
| 著者所属 | ||||||
| 値 | Intensive Care Unit and Department of Anesthesiology, University of Hirosaki, Graduate School of Medicine | |||||
| 著者所属 | ||||||
| 値 | Intensive Care Unit and Department of Anesthesiology, University of Hirosaki, Graduate School of Medicine | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To investigated the eff ect of high volume continuous hemofi ltration（ HVHF） on the lung lesion observed with transesophageal echocardiography （TEE） in endotoxin-induced acute lung injury in piglets. Piglets weighing 20-30kg. Interventions: After endotoxin of 20 μg/kg intravenous administration, animals were randomly assigned to control group（ n=7） and HVHF group（ n=7）. In both group, fi ltration was performed for fi ve hours and zero balanced. Filtration fl ow was 150 ml/hr in HVHF group and 0ml/hr in control group. The area of the lesion, resistive index and maximal blood velocity in regional pulmonary artery were estimated using TEE. High mobility group B1 protein （HMGB1）, cortisol and catecholamine concentrations were measured in plasma at endotoxin 5 hours. Measurements of blood gas, hemodynamics and TEE images were obtained every hour. The value of PaO2, density area and resistive index were 70.0±8.8 mmHg, 10.7±4.5 cm2 and 0.61±0.23 in control group and 120.4±20.3 mmHg, 3.3±2.0 cm2 and 0.88 ±0.22 in HVHF group at endotoxin 5 hours respectively（ mean±SD）. PaO2 and resistive index increased, and density area decreased in HVHF group than those of control group signifi cantly（ p<0.05, respectively）. There was signifi cant relationship between PaO2 and density area （r=0.76, p<0.01）. There was no signifi cant diff erence in hemodynamics, HMGB1, cortisol and catecholamines concentration in plasma and morphometry between control group and HVHF group. In conclusion, these results suggest that non-specifi c blood purifi cation with HVHF improves arterial oxygenation and lung image observed with TEE in endotoxin-induced acute lung injury in piglets. |
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| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 弘前医学. 59(Suppl.), 2007, p.S128-S136 | |||||
| 書誌情報 |
弘前医学 巻 59, 号 Supplement, p. S128-S136, 発行日 2007-11-29 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0439-1721 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00211444 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 492.8 | |||||
| NIIサブジェクト | ||||||
| 主題Scheme | Other | |||||
| 主題 | 医学 | |||||
| 出版者 | ||||||
| 出版者 | 弘前大学大学院医学研究科・弘前医学会 | |||||
| 資源タイプ | ||||||
| 値 | Article | |||||
