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  1. 30 医学部・医学研究科・保健学研究科
  2. 30b 弘前医学 = Hirosaki Medical Journal
  3. 59巻Supplement

Continuous venovenous hemofi ltration improves endotoxin induced lung injury in pigs : Evaluation with ultrasonography

http://hdl.handle.net/10129/2226
http://hdl.handle.net/10129/2226
02e1700d-742b-487e-9f5f-77bbf627372d
名前 / ファイル ライセンス アクション
HirosakiMedJ_59_S128.pdf HirosakiMedJ_59_S128.pdf (907.0 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2009-09-18
タイトル
タイトル Continuous venovenous hemofi ltration improves endotoxin induced lung injury in pigs : Evaluation with ultrasonography
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 Tsubo, Toshihito

× Tsubo, Toshihito

Tsubo, Toshihito

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Fujita, Ayaka

× Fujita, Ayaka

Fujita, Ayaka

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Hashiba, Eiji

× Hashiba, Eiji

Hashiba, Eiji

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Ishihara, Hironori

× Ishihara, Hironori

Ishihara, Hironori

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Hirota, Kazuyoshi

× Hirota, Kazuyoshi

Hirota, Kazuyoshi

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著者所属
値 Intensive Care Unit and Department of Anesthesiology, University of Hirosaki, Graduate School of Medicine
著者所属
値 Intensive Care Unit and Department of Anesthesiology, University of Hirosaki, Graduate School of Medicine
著者所属
値 Intensive Care Unit and Department of Anesthesiology, University of Hirosaki, Graduate School of Medicine
著者所属
値 Intensive Care Unit and Department of Anesthesiology, University of Hirosaki, Graduate School of Medicine
著者所属
値 Intensive Care Unit and Department of Anesthesiology, University of Hirosaki, Graduate School of Medicine
抄録
内容記述タイプ Abstract
内容記述 To investigated the eff ect of high volume continuous hemofi ltration( HVHF) on the lung lesion observed
with transesophageal echocardiography (TEE) in endotoxin-induced acute lung injury in piglets. Piglets weighing
20-30kg. Interventions: After endotoxin of 20 μg/kg intravenous administration, animals were randomly assigned to
control group( n=7) and HVHF group( n=7). In both group, fi ltration was performed for fi ve hours and zero balanced.
Filtration fl ow was 150 ml/hr in HVHF group and 0ml/hr in control group. The area of the lesion, resistive index
and maximal blood velocity in regional pulmonary artery were estimated using TEE. High mobility group B1 protein
(HMGB1), cortisol and catecholamine concentrations were measured in plasma at endotoxin 5 hours. Measurements of
blood gas, hemodynamics and TEE images were obtained every hour. The value of PaO2, density area and resistive
index were 70.0±8.8 mmHg, 10.7±4.5 cm2 and 0.61±0.23 in control group and 120.4±20.3 mmHg, 3.3±2.0 cm2 and 0.88
±0.22 in HVHF group at endotoxin 5 hours respectively( mean±SD). PaO2 and resistive index increased, and density
area decreased in HVHF group than those of control group signifi cantly( p<0.05, respectively). There was signifi cant
relationship between PaO2 and density area (r=0.76, p<0.01). There was no signifi cant diff erence in hemodynamics,
HMGB1, cortisol and catecholamines concentration in plasma and morphometry between control group and HVHF
group. In conclusion, these results suggest that non-specifi c blood purifi cation with HVHF improves arterial oxygenation
and lung image observed with TEE in endotoxin-induced acute lung injury in piglets.
引用
内容記述タイプ Other
内容記述 弘前医学. 59(Suppl.), 2007, p.S128-S136
書誌情報 弘前医学

巻 59, 号 Supplement, p. S128-S136, 発行日 2007-11-29
ISSN
収録物識別子タイプ ISSN
収録物識別子 0439-1721
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00211444
フォーマット
内容記述タイプ Other
内容記述 application/pdf
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
日本十進分類法
主題Scheme NDC
主題 492.8
NIIサブジェクト
主題Scheme Other
主題 医学
出版者
出版者 弘前大学大学院医学研究科・弘前医学会
資源タイプ
値 Article
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