| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2009-09-18 |
| タイトル |
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|
タイトル |
Retinoic acid-inducible gene-I（ RIG-I） and diseases |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
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主題Scheme |
Other |
|
主題 |
RIG-I |
| キーワード |
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主題Scheme |
Other |
|
主題 |
infectious diseases |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
infl ammatory diseases |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Imaizumi, Tadaatsu
Mori, Fumiaki
Yagihashi, Norito
Kitamura, Hideo
Sashinami, Hiroshi
Suzuki, Koichi
Yamashita, Koji
Taima, Kageaki
Kubota, Kosei
Tanji, Kunikazu
Sakaki, Hirotaka
Matsumiya, Tomoh
Yoshida, Hidemi
Mariya, Yasushi
Nakane, Hajime
Tanaka, Hiroshi
Takanashi, Shingo
Wakabayashi, Koichi
Yagihashi, Soroku
Nakane, Akio
Ito, Etsuro
Okumura, Ken
Kimura, Hiroto
Satoh, Kei
|
| 著者所属 |
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|
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Department of Vascular Biology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
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Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine |
| 著者所属 |
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Department of Molecular Pathology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
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Department of Dermatology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
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Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
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Department of Pediatrics, Hirosaki University Graduate School of Medicine |
| 著者所属 |
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Department of Vascular Biology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
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Department of Internal, Hirosaki University Graduate School of Medicine |
| 著者所属 |
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Department of Dentistry and Oral, Surgery, Hirosaki University Graduate School of Medicine |
| 著者所属 |
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Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
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Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
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Department of Vascular Biology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
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Department of Dermatology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
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Department of Dermatology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
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Department of Pediatrics, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
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Department of Internal, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
|
Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
|
Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
|
Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
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Department of Pediatrics, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
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Department of Internal, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
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Department of Dentistry and Oral, Surgery, Hirosaki University Graduate School of Medicine |
| 著者所属 |
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Department of Vascular Biology, Hirosaki University Graduate School of Medicine |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
Retinoic acid-inducible gene-I （RIG-I） is a cytoplasmic protein regarded as putative RNA helicase.Immunohistochemical studies revealed high levels of RIG-I expression in epidermic cells in psoriasis, in macrophagesin atherosclerotic lesions and in glomeruli of lupus nephritis. RIG-I expression was also demonstrated in macrophagesand vascular endothelial cells in experimental animals with Listeria or Hanta virus infection. In vitro studies using cellcultures revealed the expression of RIG-I, in various cells including endothelial cells, macrophages and astroglial cells, inresponse to the stimulation with cytokines, lipopolysaccharide, double-stranded RNA, Listeria monocytogenes, etc. Thestudies employing the overexpression or RNA interference suggested that RIG-I is involved in the regulation of cytokineexpression including CXCL10/IP-10 and CCL5/RANTES. These results suggest that RIG-I constitutes a part of theintracellular pathway for the regulation of infl ammatory and immune responses. |
| 引用 |
|
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内容記述タイプ |
Other |
|
内容記述 |
弘前医学. 59(Suppl.), 2007, p.S137-S142 |
| 書誌情報 |
弘前医学
巻 59,
号 Supplement,
p. S137-S142,
発行日 2007-11-29
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0439-1721 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00211444 |
| フォーマット |
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内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 日本十進分類法 |
|
|
主題Scheme |
NDC |
|
主題 |
491.8 |
| NIIサブジェクト |
|
|
主題Scheme |
Other |
|
主題 |
基礎医学 |
| 出版者 |
|
|
出版者 |
弘前大学大学院医学研究科・弘前医学会 |
| 資源タイプ |
|
|
値 |
Article |
HirosakiMedJ_59_S137.pdf (132.1 kB)
