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The role of Nrf2 in the protection against infl ammation and innate immunity
http://hdl.handle.net/10129/2232
http://hdl.handle.net/10129/2232a19fa794-bdd4-47f3-8c26-d1b7bf5a0806
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HirosakiMedJ_59_S167.pdf (139.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2009-09-18 | |||||||||
| タイトル | ||||||||||
| タイトル | The role of Nrf2 in the protection against infl ammation and innate immunity | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Nrf2 | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | antioxidant responsive element(ARE) | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | macrophage | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| 著者 |
Maruyama, Atsushi
× Maruyama, Atsushi
× Itoh, Ken
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| 著者所属 | ||||||||||
| Center for Advanced Medical Research, Hirosaki University Graduate School of Medicine | ||||||||||
| 著者所属 | ||||||||||
| Center for Advanced Medical Research, Hirosaki University Graduate School of Medicine | ||||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | NF-E2-related factor 2 （Nrf2） regulates the coordinate induction of phase 2 detoxifying and antioxidant enzymes in response to xenobiotics and oxidative stress via antioxidant responsive element. Nrf2 knockout mice are highly susceptible to the acute toxicity generated by acetaminophen, butylated hydroxytoluene or hyperoxia and to carcinogenesis induced by benzo[a]pyrene. Recently, it becomes increasingly evident that Nrf2 also plays essential roles in the protection against infl ammation. Nrf2 regulates the infl ammation during carrageenin-induced pleurisy and lung infl ammation, wound healing in skin, and dextran sulfate-induced colitis. Nrf2 knockout mice are also susceptible to endotoxin-induced septic shock and allergen-induced asthma. Using carrageenin-induced pleurisy and porcine neutrophil elastase-induced lung injury models, we proposed that this anti-infl ammatory action of Nrf2 relies on the activities in macrophages. In macrophages, Nrf2 modulates the infl ammatory response by up-regulating a range of anti-oxidative and anti-infl ammatory enzymes, such as CD36 and secretory leukoprotease inhibitor（ SLPI）. CD36 is a macrophage class B scavenger receptor involved in the uptake of apoptotic neutrophils and microorganisms such as Staphylococcus aureus. Thus, Nrf2 may play important roles in the protection of infl ammation and innate immune response. |
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| 引用 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 弘前医学. 59(Suppl.), 2007, p.S167-S171 | |||||||||
| 書誌情報 |
弘前医学 巻 59, 号 Supplement, p. S167-S171, 発行日 2007-11-29 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 0439-1721 | |||||||||
| 書誌レコードID | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AN00211444 | |||||||||
| フォーマット | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | application/pdf | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 日本十進分類法 | ||||||||||
| 主題Scheme | NDC | |||||||||
| 主題 | 491 | |||||||||
| NIIサブジェクト | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | 基礎医学 | |||||||||
| 出版者 | ||||||||||
| 出版者 | 弘前大学大学院医学研究科・弘前医学会 | |||||||||
| 資源タイプ | ||||||||||
| 値 | Article | |||||||||
