| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2009-09-18 |
| タイトル |
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タイトル |
All-trans-retinoic acid (atRA) increases host resistance to Listeria monocytogenes infection |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Hiraga, Hiroto
Sashinami, Hiroshi
Hu, Dong-Liang
Ishiguro, Yoh
Wakabayashi, Koichi
Munakata, Akihiro
Nakane, Akio
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| 著者所属 |
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Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
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Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
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Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
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Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
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Department of Molecular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine |
| 著者所属 |
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Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
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Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Dietary vitamin A is an essential precursor of tissue retinol, which participates in a variety of biological processes including innate immunity. Functions of vitamin A mainly depend on retinoic acid（ RA）, principally all-trans- RA （atRA） and 9-cis-RA. We assessed whether atRA is benefi cial in host resistance against bacterial infections or not. Vitamin A-defi cient（ VAD） mice were highly susceptible to infection with Listeria monocytogenes. Pre-treatment with atRA enhanced host resistance against L. monocytogenes infection in both VAD and VAS mice. Interferon（ IFN） -γ production in atRA pre-treated VAS mice was not higher compared with the control VAD mice. The eff ect of atRA was independent of T cells and B cells. The bactericidal activity in macrophages obtained from atRA pre-treated VAS mice was almost the same level compared with the control VAS mice. Our results demonstrated that the treatment with atRA is benefi cial for host resistance against L. monocytogenes infection in the early phase and suggested a new therapeutic possibility of atRA in bacterial infections. |
| 引用 |
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内容記述タイプ |
Other |
|
内容記述 |
弘前医学. 59(Suppl.), 2007, p.S244-S252 |
| 書誌情報 |
弘前医学
巻 59,
号 Supplement,
p. S244-S252,
発行日 2007-11-29
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0439-1721 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AN00211444 |
| フォーマット |
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内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 日本十進分類法 |
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|
主題Scheme |
NDC |
|
主題 |
491 |
| NIIサブジェクト |
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主題Scheme |
Other |
|
主題 |
基礎医学 |
| 出版者 |
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出版者 |
弘前大学大学院医学研究科・弘前医学会 |
| 資源タイプ |
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値 |
Article |
HirosakiMedJ_59_S244.pdf (408.8 kB)
