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Upregulation of Insulin-Like Growth Factor-1 Gene Expression in Cardiac Myocytes by Hypoxia : Mechanism for Its Cardioprotective Effect
http://hdl.handle.net/10129/1796
http://hdl.handle.net/10129/1796e2b2cb77-3fae-4206-9b25-70ebbbc12d46
名前 / ファイル | ライセンス | アクション |
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HirosakiMedJ_60_1-4_36.pdf (340.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-04-08 | |||||
タイトル | ||||||
タイトル | Upregulation of Insulin-Like Growth Factor-1 Gene Expression in Cardiac Myocytes by Hypoxia : Mechanism for Its Cardioprotective Effect | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cardiac myocytes | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cardiac fibroblasts | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | insulin-like growth factor-1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | hypoxia | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kato, Chisato
× Kato, Chisato× Osanai, Tomohiro× Shibutani, Shuji× Hanada, Kenji× Okumura, Ken |
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著者(ヨミ) | ||||||
姓名 | カトウ, チサト | |||||
著者(ヨミ) | ||||||
姓名 | オサナイ, トモヒロ | |||||
著者(ヨミ) | ||||||
姓名 | シブタニ, シュウジ | |||||
著者(ヨミ) | ||||||
姓名 | ハナダ, ケンジ | |||||
著者(ヨミ) | ||||||
姓名 | オクムラ, ケン | |||||
著者別名 | ||||||
姓名 | 加藤, 千里 | |||||
著者別名 | ||||||
姓名 | 長内, 智宏 | |||||
著者別名 | ||||||
姓名 | 渋谷, 修司 | |||||
著者別名 | ||||||
姓名 | 花田, 賢二 | |||||
著者別名 | ||||||
姓名 | 奥村, 謙 | |||||
著者所属 | ||||||
Department of Cardiology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Cardiology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Cardiology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Cardiology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Cardiology, Hirosaki University Graduate School of Medicine | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Insulin-like growth factor (IGF)-1 is known to exert benefi cial eff ects on the heart, but its source and function under hypoxia are unknown. We investigated the eff ect of hypoxia on IGF-1 expression and its role in the regeneration in the heart. Cardiac myocytes and fi broblasts obtained from neonate mice heart were cultured and exposed to hypoxia. mRNA of IGF-1, IGF-binding protein 3 (IGFBP3), and vascular endothelial growth factor-A (VEGF-A) was measured by real-time PCR. In cardiac myocytes, IGF-1 mRNA was increased by 3.5±1.1 fold at 3 hours after hypoxia concomitantly with the increase in IGFBP3 and VEGF-A mRNA, and returned to the baseline at 24 hours. In contrast, IGF-1 mRNA in cardiac fi broblasts was unchanged by hypoxia, although VEGF-A mRNA was increased. To investigate the role of IGF-1 in the heart regeneration, we measured the gene expressions of stromal cell-derived factor-1( SDF-1), its receptor CXCR4, and matrix metalloproteinase( MMP)-14 related to cell homing. In cardiac myocytes, SDF-1 and MMP-14 mRNA were increased at 3 hours after hypoxia and tended to be positively correlated with IGF-1 mRNA. These suggest that hypoxia increases IGF-1 expression in cardiac myocytes, and this endogenous IGF-1 may exert benefi cial eff ects on regeneration in the heart. |
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引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 弘前医学. 60(1/2/3/4), 2009, p.36-44 | |||||
書誌情報 |
弘前医学 巻 60, 号 1/2/3/4, p. 36-44, 発行日 2009-03-31 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0439-1721 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00211444 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
日本十進分類法 | ||||||
主題Scheme | NDC | |||||
主題 | 491.3 | |||||
その他のタイトル | ||||||
その他のタイトル | 低酸素による心筋細胞Insulin-like growth factor-1 遺伝子発現亢進の役割 : 心保護作用の機序について | |||||
タイトル(ヨミ) | ||||||
その他のタイトル | テイサンソ ニヨル シンキン サイボウ Insulin-like growth factor-1 イデンシ ハツゲン コウシン ノ ヤクワリ : シン ホゴ サヨウ ノ キジョ ニツイテ | |||||
NIIサブジェクト | ||||||
主題Scheme | Other | |||||
主題 | 内科系臨床医学 | |||||
出版者 | ||||||
出版者 | 弘前大学大学院医学研究科・弘前医学会 | |||||
資源タイプ | ||||||
値 | Article |