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Reconstitution of the Immune System after Murine Allogeneic Umbilical Cord Blood Transplantation
http://hdl.handle.net/10129/3278
http://hdl.handle.net/10129/32780f00e5c4-859a-4c5b-858a-2b690c3c44e2
名前 / ファイル | ライセンス | アクション |
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HirosakiMedJ_61(1)_35.pdf (618.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-03-29 | |||||
タイトル | ||||||
タイトル | Reconstitution of the Immune System after Murine Allogeneic Umbilical Cord Blood Transplantation | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | umbilical cord blood | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | reconstitution of immune system | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | allogeneic UCBC transplantation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 臍帯血 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 免疫系再構築 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 不適合臍帯血移植 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Sato, Hideaki
× Sato, Hideaki× Sato, Masashi× Chiba, Makie× Ito, Kyoko× Ito, Koichi |
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著者(ヨミ) | ||||||
姓名 | サトウ, ヒデアキ | |||||
著者(ヨミ) | ||||||
姓名 | サトウ, マサシ | |||||
著者(ヨミ) | ||||||
姓名 | チバ, マキエ | |||||
著者(ヨミ) | ||||||
姓名 | イトウ, キョウコ | |||||
著者(ヨミ) | ||||||
姓名 | イトウ, コウイチ | |||||
著者別名 | ||||||
姓名 | 佐藤, 英明 | |||||
著者別名 | ||||||
姓名 | 佐藤, 雅 | |||||
著者別名 | ||||||
姓名 | 千葉, 真希枝 | |||||
著者別名 | ||||||
姓名 | 伊藤, 京子 | |||||
著者別名 | ||||||
姓名 | 伊藤, 巧一 | |||||
著者所属 | ||||||
Department of Biomedical Sciences, Hirosaki University Graduate School of Health Sciences | ||||||
著者所属 | ||||||
Department of Medical Technology, Hirosaki University School of Health Sciences | ||||||
著者所属 | ||||||
Department of Medical Technology, Hirosaki University School of Health Sciences | ||||||
著者所属 | ||||||
Department of Biomedical Sciences, Hirosaki University Graduate School of Health Sciences | ||||||
著者所属 | ||||||
Department of Biomedical Sciences, Hirosaki University Graduate School of Health Sciences | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The ability of murine allogeneic umbilical cord blood cells (UCBCs) to reconstitute the immune system was investigated. UCBCs obtained from fetuses of C57BL/6 (B6; H-2b) mice, which were transgenic for green fluorescent protein (GFP), were transplanted into RAG2 (-/-) BALB/c mice (H-2d). After transplantation, flow cytometric analysis revealed successful reconstitution of phenotypically mature GFP-positive immune cells of donor origin, including T cells, B cells, monocytes, and granulocytes in the peripheral blood of the recipient mice. Analysis of functional maturation of lymphocytes revealed that 2,4,6-trinitrophenyl-keyhole limpet hemocyanin (TNP-KLH) -immunized UCBC-transplanted recipients produced both TNP-specific IgM and IgG antibodies. These results indicated that the recipient mice were capable of mounting antibody responses to T-dependent antigens; further, Ig class switching from IgM to IgG confi rmed that both B cells and CD4+ helper T cells derived from allogeneic UCBCs were immunologically competent. Furthermore, mice transplanted with allogeneic UCBCs accepted skin grafts from both B6 and BALB/c mice. However, these chimeric mice completely rejected skin grafts from third party C3H/ HeJ (H-2k) mice, indicating the presence of functional CD8+ killer T cells as well as CD4+ helper T cells. In terms of potential clinical application, our results indicate that allogeneic UCBC transplantation can enable recovery of the normal immune system in recipients. |
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引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 弘前医学. 61(1), 2010, p.35-45 | |||||
書誌情報 |
弘前医学 巻 61, 号 1, p. 35-45, 発行日 2010-03-25 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0439-1721 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00211444 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
日本十進分類法 | ||||||
主題Scheme | NDC | |||||
主題 | 493.1 | |||||
その他のタイトル | ||||||
その他のタイトル | マウス同種異系臍帯血移植による免疫系の再構築 | |||||
タイトル(ヨミ) | ||||||
その他のタイトル | マウス ドウシュ イケイ サイタイケツ イショク ニヨル メンエキケイ ノ サイコウチク | |||||
NIIサブジェクト | ||||||
主題Scheme | Other | |||||
主題 | 内科系臨床医学 | |||||
出版者 | ||||||
出版者 | 弘前大学出版会 | |||||
資源タイプ | ||||||
値 | Article |