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Possible Function of Neuronal Leucine-Rich Repeat Protein 3( NLRR3) in Primary Immune Response
http://hdl.handle.net/10129/3279
http://hdl.handle.net/10129/3279eb433bea-8744-4efd-a3cb-d4540460c894
名前 / ファイル | ライセンス | アクション |
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HirosakiMedJ_61(1)_46.pdf (482.9 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-03-29 | |||||
タイトル | ||||||
タイトル | Possible Function of Neuronal Leucine-Rich Repeat Protein 3( NLRR3) in Primary Immune Response | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | neuronal leucine-rich repeat protein | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | integrin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | RGD motif | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | dendritic cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | adhesion molecule | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 神経関連ロイシンリッチリピートタンパク質 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | インテグリン | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | RGD モチーフ | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 樹状細胞 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 接着分子 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ito, Kyoko
× Ito, Kyoko× Masuko, Kazutaka× Ito, Koichi |
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著者(ヨミ) | ||||||
姓名 | イトウ, キョウコ | |||||
著者(ヨミ) | ||||||
姓名 | マスコ, カズタカ | |||||
著者(ヨミ) | ||||||
姓名 | イトウ, コウイチ | |||||
著者別名 | ||||||
姓名 | 伊藤, 京子 | |||||
著者別名 | ||||||
姓名 | 増子, 和尚 | |||||
著者別名 | ||||||
姓名 | 伊藤, 巧一 | |||||
著者所属 | ||||||
Department of Biomedical Sciences, Hirosaki University Graduate School of Health Sciences | ||||||
著者所属 | ||||||
Department of Medical Technology, Hirosaki University School of Health Sciences | ||||||
著者所属 | ||||||
Department of Biomedical Sciences, Hirosaki University Graduate School of Health Sciences | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Contact between dendritic cells( DCs) and resting T cells is essential for initiation of the primary immune response. In this study, we examined whether neuronal leucine-rich repeat protein 3 (NLRR3), a receptor involved in nerve system development, participates in DC-T cell binding and T-cell activation. We confirmed that NLRR3 is expressed on naive T cells. NLRR3 contains an Arg-Gly-Asp (RGD) motif in its amino acid sequence, for which several integrins can be considered as potential ligands. Indeed, monocyte-derived DCs expressed several integrins that can bind to the RGD motif. Functionally, DC-induced resting allogeneic T-cell proliferation was partially inhibited by addition of integrin-specific antibodies and synthetic RGD peptides, indicating that RGD-containing molecules, including NLRR3 and several integrins, at least participate in the events of the initial primary immune response involving naive T cells and DCs. Furthermore, DCs were shown to bind directly to NLRR3-transfected Chinese hamster ovary cells in a NLRR3-dependent manner, and the binding was removed in the presence of integrin-specifi c antibodies. These data suggest that NLRR3 plays an important role in initiation of the primary immune response. |
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引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 弘前医学. 61(1), 2010, p.46-57 | |||||
書誌情報 |
弘前医学 巻 61, 号 1, p. 46-57, 発行日 2010-03-25 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0439-1721 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00211444 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
日本十進分類法 | ||||||
主題Scheme | NDC | |||||
主題 | 491 | |||||
その他のタイトル | ||||||
その他のタイトル | 一次免疫応答におけるNeuronal leucine-rich repeat protein 3(NLRR3)の機能的役割 | |||||
タイトル(ヨミ) | ||||||
その他のタイトル | イチジ メンエキ オウトウ ニオケル Neuronal leucine-rich repeat protein 3 (NLRR3) ノ キノウテキ ヤクワリ | |||||
NIIサブジェクト | ||||||
主題Scheme | Other | |||||
主題 | 基礎医学 | |||||
出版者 | ||||||
出版者 | 弘前大学出版会 | |||||
資源タイプ | ||||||
値 | Article |