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＜Poster＞The role of interleukin-17 in the protective effect of an immunization with clumping factor A against Staphylococcus aureus infection
http://hdl.handle.net/10129/3694
http://hdl.handle.net/10129/36945c2aedee-a184-4339-8e5a-a26fa0286102
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HirosakiMedJ_61_S238.pdf (160.0 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||
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| 公開日 | 2010-08-19 | |||||||||||
| タイトル | ||||||||||||
| タイトル | ＜Poster＞The role of interleukin-17 in the protective effect of an immunization with clumping factor A against Staphylococcus aureus infection | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Staphylococcus aureus | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Clumping factor A | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Immunization | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | IL-17 | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Th17 | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| 著者 |
Narita, Koji
× Narita, Koji
× Hu, Dong-Liang
× Nakane, Akio
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| 著者(ヨミ) | ||||||||||||
| 識別子Scheme | WEKO | |||||||||||
| 識別子 | 11494 | |||||||||||
| 姓名 | ナリタ, コウジ | |||||||||||
| 著者(ヨミ) | ||||||||||||
| 識別子Scheme | WEKO | |||||||||||
| 識別子 | 11493 | |||||||||||
| 姓名 | フウ, ドンリャン | |||||||||||
| 著者(ヨミ) | ||||||||||||
| 識別子Scheme | WEKO | |||||||||||
| 識別子 | 11501 | |||||||||||
| 姓名 | ナカネ, アキオ | |||||||||||
| 著者所属 | ||||||||||||
| Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine | ||||||||||||
| 著者所属 | ||||||||||||
| Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine | ||||||||||||
| 著者所属 | ||||||||||||
| Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine | ||||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Clumping factor A （ClfA） is an adhesin of Staphylococcus aureus, and the residues 40-559 of ClfA （ClfA40-559） compose fi brinogen binding domain. It was reported that antibody to ClfA40-559 plays an important role in the protective eff ects. In this study, we investigated the role of IL-17 in the protective eff ects of an immunization with ClfA40-559 against S. aureus infection. Mice immunized or non-immunized with ClfA40-559 were challenged with S. aureus. Bacterial numbers in the organs and survival rates were evaluated. RAW264.7, DC2.4 and spleen cells of naïve and immunized mice were stimulated with ClfA40-559. Cytokine production and mRNA expression in the spleens and cells was determined by ELISA and/or RT-PCR. The survival rate was improved and the bacterial numbers in the organs were reduced in the mice immunized with ClfA40-559. ClfA40-559 induced IL-23p19 mRNA expression and IL-6 but not IL-12 production in DC2.4 and RAW264.7 cells. RORγt and IL-17A mRNA expression in the spleen cells of naïve mice was induced. In the spleen cells of immunized mice, ClfA40-559 induced the high production of IL-17 but not IFN-γ or IL-4. IL-17A, IL-6 and CXCL2 mRNA expression was also increased in the organs of immunized and challenged mice. These results suggest that an immunization with ClfA40-559 induces Th17, and that IL-17 contributes to host defense in early phase of S. aureus infection by promoting neutrophil recruitment. |
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| 引用 | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | 弘前医学. 61(Suppl.), 2010, p.S238-S244 | |||||||||||
| 書誌情報 |
弘前医学 巻 61, 号 Supplement, p. S238-S244, 発行日 2010-07-08 |
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| ISSN | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 0439-1721 | |||||||||||
| 書誌レコードID | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AN00211444 | |||||||||||
| 著者版フラグ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| 日本十進分類法 | ||||||||||||
| 主題Scheme | NDC | |||||||||||
| 主題 | 490 | |||||||||||
| NIIサブジェクト | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | 医学 | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | 弘前大学大学院医学研究科・弘前医学会 | |||||||||||
| 資源タイプ | ||||||||||||
| 値 | Article | |||||||||||
