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Two Contradictory Roles of Hyaluronan in an Experimental Rat Acute Pancreatitis Model
http://hdl.handle.net/10129/6149
http://hdl.handle.net/10129/614931bed6f7-07c0-491d-8f3a-88df784e6a03
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HirosakiMedJ_68(1)_62.pdf (461.6 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||
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| 公開日 | 2017-10-23 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | Two Contradictory Roles of Hyaluronan in an Experimental Rat Acute Pancreatitis Model | |||||||||||||||
| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | hyaluronan; 4-methylumbelliferone | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | acute pancreatitis | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | pro-inflammatory cytokine | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| 資源タイプ | journal article | |||||||||||||||
| 著者 |
Igarashi, Go
× Igarashi, Go
× Sawada, Naoya
× Kimura, Masayo
× Endo, Tetsu
× Fukuda, Shinsaku
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| 著者所属 | ||||||||||||||||
| Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine | ||||||||||||||||
| 著者所属 | ||||||||||||||||
| Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine | ||||||||||||||||
| 著者所属 | ||||||||||||||||
| Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine | ||||||||||||||||
| 著者所属 | ||||||||||||||||
| Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine | ||||||||||||||||
| 著者所属 | ||||||||||||||||
| Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine | ||||||||||||||||
| 抄録 | ||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||
| 内容記述 | Hyaluronan plays a role not only as a structural component but also in the regulation of inflammatory processes. However, the role of hyaluronan in acute pancreatitis is not clear. In this study, we have explored the role of hyaluronan in a rat acute pancreatitis model using a hyaluronan synthesis inhibitor, 4-methylumbelliferone（ 4-MU）. Methods: Six-week-old male Sprague-Dawley rats were fed a standard diet or the same diet containing 5% 4-MU beginning two weeks before induction of cerulean- and lipopolysaccharide-induced acute pancreatitis. The severity of acute pancreatitis and pro-inflammatory cytokine levels were evaluated with or without pretreatment with 4-MU. Results: Before development of acute pancreatitis, 4-MU pretreatment reduced serum hyaluronan levels. After development of acute pancreatitis, 4-MU pretreatment increased serum amylase level and blood urea nitrogen/creatinine ratio. However, 4-MU pretreatment suppressed tumor necrosis factor-α （TNF- α） production in acute pancreatitis. Conclusions: Systemic inhibition of hyaluronan exacerbated acute pancreatitis in spite of suppression of TNF-α production. These data suggest that hyaluronan has two completely different effects, i.e., a barrier function and as a regulator of inflammation in acute pancreatitis. The results emphasize that further analysis that takes into account the molecular size of hyaluronan is needed since it may explain the contradictory findings. |
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| 引用 | ||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||
| 内容記述 | 弘前医学. 68, p.62-70. 2017 | |||||||||||||||
| 書誌情報 |
弘前医学 巻 68, 号 1, p. 62-70, 発行日 2017-10-05 |
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| ISSN | ||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||
| 収録物識別子 | 0439-1721 | |||||||||||||||
| 書誌レコードID | ||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||
| 収録物識別子 | AN00211444 | |||||||||||||||
| 著者版フラグ | ||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||
| 日本十進分類法 | ||||||||||||||||
| 主題Scheme | NDC | |||||||||||||||
| 主題 | 490 | |||||||||||||||
| NIIサブジェクト | ||||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | 医学 | |||||||||||||||
| 出版者 | ||||||||||||||||
| 出版者 | 弘前大学大学院医学研究科・弘前医学会 | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 値 | Article | |||||||||||||||
