| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2019-04-10 |
| タイトル |
|
|
タイトル |
Vitamin a Deficiency Impairs Host Resistance to Listeria Monocytogenes Infection Through Excessive Apoptosis of macrophages |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Vitamin A |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Vitamin A deficiency |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
macrophage |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Listeria monocytogenes |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
apoptosis |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Tanaka, Nahoko
Hiraga, Hiroto
Sakuraba, Hirotake
Murai, Yasuhisa
Maeda, Takato
Watanabe, Rina
Ota, Shinji
Akemoto, Yui
Hasui, Keisuke
Yoshida, Shukuko
Asano, Krisana
Nakane, Akio
Fukuda, Shinsaku
|
| 著者所属 |
|
|
|
Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
|
Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
|
Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
|
Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
|
Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
|
Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
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Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
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Department of Pathology and Laboratory Medicine, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
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Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
|
Shibata Irika Co |
| 著者所属 |
|
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Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
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Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
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Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Vitamin A is essential for maintenance of homeostasis, and it also regulates various immune mechanisms.Listeria monocytogenes is a gram-positive bacillus that invades the cytoplasm of phagocytes and performs intracellular multiplication, and is often used as a tool for functional analysis of macrophages. In this study, we investigated the changes of macrophages under vitamin A deficiency（ VAD） using L. monocytogenes. During L. monocytogenes infection,apoptosis was increased in CD11b-positive splenocytes of VAD mice compared with vitamin A sufficient （VAS）mice. A similar result was obtained with peritoneal exudate cells （PECs）. Significant increase of apoptosis due to the administration of Ro41-5253, an inhibitor of retinoic acid receptor, was also observed in the macrophage cell line RAW264.7. Furthermore, in VAD mice, the number of bacteria in the spleens and livers was significantly increased.These results suggest that excessive apoptosis of macrophages occurs under VAD condition, leading to impaired host resistance to L. monocytogenes. Taken together, vitamin A contributes to the maintenance of homeostasis by regulating macrophage functions, indicating the importance of vitamin A supplementation. |
| 書誌情報 |
弘前医学
巻 69,
号 1-4,
p. 163-171,
発行日 2019-03-15
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0439-1721 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00211444 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 日本十進分類法 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 出版者 |
|
|
出版者 |
弘前大学大学院医学研究科・弘前医学会 |
HirosakiMedJ_69(1-4)_163.pdf (902.5 kB)
