| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2015-05-25 |
| タイトル |
|
|
タイトル |
Comparison of the Effects of Isoflurane Inhalation, Pentobarbital and a Medetomidine-Midazolam-Butorphanol Combination Anesthesia on Electrocardiograms in Mice |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
inhalation anesthesia |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
isoflurane |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
propofol |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
pentobarbital |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
medetomidine |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
midazolam |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Shintaku, Tomohiro
Ohba, Takayoshi
Niwa, Hidetoshi
Kushikata, Tetsuya
Hirota, Kazuyoshi
Ono, Kyoichi
Mariya, Yasushi
Imaizumi, Tadaatsu
Sawamura, Daisuke
Murakami, Manabu
|
| 著者所属 |
|
|
|
Department of Pharmacology,Hirosaki University Graduate School ofedicine |
| 著者所属 |
|
|
|
Department of Cell Physiology, Akita University, Graduate School of Medicine |
| 著者所属 |
|
|
|
Department of Anesthesiology ,Hirosaki University Graduate School ofedicine |
| 著者所属 |
|
|
|
Department of Anesthesiology, Hirosaki University Graduate School ofedicine |
| 著者所属 |
|
|
|
Department of Anesthesiology, Hirosaki University Graduate School ofedicine |
| 著者所属 |
|
|
|
Department of Cell Physiology, Akita University, Graduate School of Medicine |
| 著者所属 |
|
|
|
Department of Dermatology, Hirosaki University Graduate School ofedicine |
| 著者所属 |
|
|
|
Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine |
| 著者所属 |
|
|
|
Department of Dermatology, Hirosaki University Graduate School ofedicine |
| 著者所属 |
|
|
|
Department of Pharmacology Hirosaki University Graduate School ofedicine |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
We compared the effects of inhalation anesthesia（ 2% isoflurane）, intraperitoneal injection of pentobarbital anesthesia （50 mg/kg）, and a combination anesthetic consisting of medetomidine, midazolam and butorphanol （MMB） on electrocardiograms in mice. Using either isoflurane inhalation anesthesia or pentobarbital anesthesia, heart rate （HR） was in the acceptable range （ca. 450-500 bpm）. In contrast, MMB anesthesia decreased HR significantly. Importantly, MMB anesthesia responded minimally to propranolol （β-blocker）, suggesting that MMB anesthesia affects sympathetic tonus and is not suitable for evaluation of the cardiovascular or sympathetic system. We confirmed that modified MMB, with a decreased dose of medetomidine from the original protocol（ an α2 agonist）, was associated with a HR of 400 bpm and a diminished response to propranolol. Our present results illustrate the importance of using an appropriate form of anesthesia suitable for experimental pharmacological studies. |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
弘前医学. 66, 2015, p.15-21 |
| 書誌情報 |
弘前医学
巻 66,
号 1,
p. 15-21,
発行日 2015-04-06
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0439-1721 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00211444 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 日本十進分類法 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| NIIサブジェクト |
|
|
主題Scheme |
Other |
|
主題 |
医学 |
| 出版者 |
|
|
出版者 |
弘前大学大学院医学研究科・弘前医学会 |
| 資源タイプ |
|
|
値 |
Article |
HirosakiMedJ_66(1)_15.pdf (1.1 MB)
